Evidence map›Paper›PMID 31866803›Full record

ArticleAdvanced functional materials2012

A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads.

Meng-Yi Bai, Christine H Moran, Lei Zhang, Changjun Liu, Yu Zhang, Lihong V Wang, Younan Xia

Abstract read
In one paragraph

Article in Advanced functional materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Nanobottles for Controlled Release and Drug Delivery.Advanced healthcare materials · 2021
    Review
  4. Phase-Change Materials for Controlled Release and Related Applications.Advanced materials (Deerfield Beach, Fla.) · 2020
    Review
  5. Article
  6. Review
  7. Article
  8. Imaging Biomaterial-Tissue Interactions.Trends in biotechnology · 2018
    Review
  9. Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017
    Review
  10. Digital design of multimaterial photonic particles.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  11. Article
  12. Article
  13. In-fiber production of polymeric particles for biosensing and encapsulation.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  14. Photoacoustic Microscopy in Tissue Engineering.Materials today (Kidlington, England) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meng-Yi BaiDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Christine H MoranDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Lei ZhangDepartment of Medicine, Washington University Medical School, Saint Louis, MO 63110, USA.
Changjun LiuDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Yu ZhangDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Lihong V WangDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Younan XiaDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.

Funding

NIH Director's Pioneer AwardDP1OD000798 · OD · WASHINGTON UNIVERSITY · PI XIA, YOUNAN · 2006 to 2010
$3.8M
NIH HHS DP1 OD000798
6 · The paper itself

Abstract

Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 °C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.

Identifiers

PMID31866803
PMCPMC6924621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.