Evidence map›Paper›PMID 31866799›Full record

ArticleContrast media & molecular imaging2019

Empirical and Theoretical Characterization of the Diffusion Process of Different Gadolinium-Based Nanoparticles within the Brain Tissue after Ultrasound-Induced Permeabilization of the Blood-Brain Barrier.

Allegra Conti, Rémi Magnin, Matthieu Gerstenmayer, Nicolas Tsapis, Erik Dumont, Olivier Tillement, François Lux, Denis Le Bihan, Sébastien Mériaux, Stefania Della Penna and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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  6. Review
  7. Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  8. Review
  9. Transport in the Brain Extracellular Space: Diffusion, but Which Kind?International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Allegra ContiNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.ORCID 0000-0003-4210-5065
Rémi MagninNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.
Matthieu GerstenmayerNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.
Nicolas TsapisInstitut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.ORCID 0000-0003-2095-2626
Erik DumontImage Guided Therapy, Pessac, France.
Olivier TillementUniversity Lyon 1, Lyon, France.
François LuxUniversity Lyon 1, Lyon, France.ORCID 0000-0003-1568-0240
Denis Le BihanNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.
Sébastien MériauxNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.ORCID 0000-0001-7430-8348
Stefania Della PennaDepartment of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Techniques, G. D'Annunzio University, Chieti, Italy.ORCID 0000-0001-5067-4327
Benoit LarratNeuroSpin, Institut des Sciences de La Vie Frédéric Joliot, Direction de La Recherche Fondamentale, Commissariat à L'Energie Atomique et Aux Energies Alternatives, Université Paris Saclay, Gif-sur-Yvette, France.
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRUniversité Claude Bernard Lyon 1 · FRInstitut de Chirurgie Guidée par l'Image · FRUniversité Paris-Sud · FRUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-intensity focused ultrasound (FUS), combined with microbubbles, is able to locally, and noninvasively, open the blood-brain barrier (BBB), allowing nanoparticles to enter the brain. We present here a study on the diffusion process of gadolinium-based MRI contrast agents within the brain extracellular space after ultrasound-induced BBB permeabilization. Three compounds were tested (MultiHance, Gadovist, and Dotarem). We characterized their diffusion through

Indexed as

Capillary PermeabilityMicrobubblesNanoconjugatesUltrasonic WavesAlgorithmsAnimalsBlood-Brain BarrierContrast MediaCorpus StriatumDiffusionExtracellular SpaceHeterocyclic CompoundsMaleMeglumineOrganometallic CompoundsParticle Sizecontrast agent BR1Contrast Mediagadobenic acidgadobutrolgadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateHeterocyclic CompoundsMeglumineNanoconjugatesOrganometallic CompoundsPhospholipidsSulfur Hexafluoride

Identifiers

PMID31866799
PMCPMC6914891
OpenAlexW2992313442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.