Evidence map›Paper›PMID 31866771›Full record

ArticleJournal of interventional cardiology2019

Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients.

Guo-Fu Zhu, Tianshu Chu, Zhimin Ruan, Mingguo Zhang, Mingli Zhou, Qian Zhang, Ran Zhang, Liyong Wu

Open access · goldAbstract read
In one paragraph

Article in Journal of interventional cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Article
  6. miRNAs in Heart Development and Disease.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Guo-Fu ZhuDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0003-2823-0046
Tianshu ChuDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0002-5965-8232
Zhimin RuanDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0002-7482-8340
Mingguo ZhangDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0002-6698-3017
Mingli ZhouDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.
Qian ZhangDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0003-4434-8773
Ran ZhangDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0002-7310-667X
Liyong WuDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.ORCID https://orcid.org/0000-0002-3840-9130
Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the association between inflammation-related microRNAs (miR-21, 146a, 155) and the plaque stability in coronary artery disease patients.

methodsThe expression of miR-21, 146a, and 155 was measured by real-time PCR in 310 consecutive patients. The level of hs-CRP, IL-6, and IL-8 was measured by ELISA. The plaque stability of coronary stenotic lesions was evaluated with intravascular ultrasound (IVUS).

results(1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (

conclusionsThe expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability.

Indexed as

Coronary Artery DiseaseCoronary StenosisC-Reactive ProteinFemaleHumansInterleukin-6Interleukin-8Leukocytes, MononuclearMaleMicroRNAsMiddle AgedPlaque, AtheroscleroticReal-Time Polymerase Chain ReactionUltrasonography, InterventionalC-Reactive ProteinInterleukin-6Interleukin-8MicroRNAs

Identifiers

PMID31866771
PMCPMC6915018
OpenAlexW2993991403

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.