ArticleCurrent biology : CB2020
Motor Behavior Selectively Inhibits Hair Cells Activated by Forward Motion in the Lateral Line of Zebrafish.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Selective genetic targeting of the mouse efferent vestibular nucleus identifies monosynaptic inputs and indicates function as multimodal integrator.Journal of neurophysiology · 2026Article
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- Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors.Science robotics · 2025Article
- Presynaptic inhibition selectively suppresses leg proprioception in behavingbioRxiv : the preprint server for biology · 2024Article
- Sensing in the dark: Constructive evolution of the lateral line system in blind populations ofEcology and evolution · 2024Review
- A synaptic corollary discharge signal suppresses midbrain visual processing during saccade-like locomotion.Nature communications · 2023Article
- Asymmetric mechanotransduction by hair cells of the zebrafish lateral line.Current biology : CB · 2023Article
- Active antennal movements in Drosophila can tune wind encoding.Current biology : CB · 2023Article
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- Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish.Current biology : CB · 2022Article
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- Sensory adaptation at ribbon synapses in the zebrafish lateral line.The Journal of physiology · 2021Article
- A neuronal blueprint for directional mechanosensation in larval zebrafish.Current biology : CB · 2021Article
- Efference copy in kinesthetic perception: a copy of what is it?Journal of neurophysiology · 2021Review
- Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum-mitochondria associations.eLife · 2021Article
- Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Characterization of Individual Projections Reveal That Neuromasts of the Zebrafish Lateral Line are Innervated by Multiple Inhibitory Efferent Cells.Frontiers in neuroanatomy · 2021Article
- The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family.Frontiers in cellular neuroscience · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
How do sensory systems disambiguate events in the external world from signals generated by the animal's own motor actions? One strategy is to use an "efference copy" of the motor command to inhibit the sensory input caused by active behavior [1]. But does inhibition of self-generated inputs also block transmission of external stimuli? We investigated this question in the lateral line, a sensory system that allows fish and amphibians to detect water currents and that contributes to behaviors such as rheotaxis [2] and predator avoidance [3, 4]. This mechanical sense begins in hair cells grouped into neuromasts dotted along the animal's body [5]. Each neuromast contains two populations of hair cells, activated by deflection in either the anterior or posterior direction [6], as well as efferent fibers that are active during motor behavior to suppress afferents projecting to the brain [7-12]. To test how far the efference copy signal modulates responses to external stimuli, we imaged neural and synaptic activity in larval zebrafish during fictive swimming. We find that efferents transmit a precise copy of the motor signal and a single spike in the motor nerve can be associated with ∼50% inhibition of glutamate release. The efference copy signal acted with high selectivity on hair cells polarized to be activated by posterior deflections, as would occur during forward motion. During swimming, therefore, "push-pull" encoding of stimulus direction by afferents of opposite polarity is disrupted while still allowing a subset of hair cells to detect stimuli originating in the external world.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.