Evidence map›Paper›PMID 31866339›Full record

ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020

An update on retinal prostheses.

Lauren N Ayton, Nick Barnes, Gislin Dagnelie, Takashi Fujikado, Georges Goetz, Ralf Hornig, Bryan W Jones, Mahiul M K Muqit, Daniel L Rathbun, Katarina Stingl and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 216 citations in OpenAlex.

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  17. Adaptation of visual responses in degeneratingFrontiers in neuroscience · 2026
    Article
  18. A deep learning framework for understanding cochlear implants.bioRxiv : the preprint server for biology · 2025
    Article
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 6 countries.

Lauren N AytonDepartment of Optometry and Vision Science and Department of Surgery (Ophthalmology), University of Melbourne, Parkville, VIC, Australia. Electronic address: layton@unimelb.edu.au.
Nick BarnesData61, CSIRO, Canberra, ACT, Australia; Australian National University, Canberra, ACT, Australia. Electronic address: Nick.Barnes@data61.csiro.au.
Gislin DagnelieLions Vision Research and Rehabilitation Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: gislin@lions.med.jhu.edu.
Takashi FujikadoDepartment of Applied Visual Science, Osaka University, Osaka, Japan. Electronic address: fujikado@ophthal.med.osaka-u.ac.jp.
Georges GoetzWaymo and Verily Life Sciences, Mountain View, CA, USA. Electronic address: ggoetz@stanford.edu.
Ralf HornigPixium Vision, Paris, France. Electronic address: rhornig@pixium-vision.com.
Bryan W JonesMoran Eye Center, School of Medicine, University of Utah, Salt Lake City, UT, USA. Electronic address: bryan.jones@m.cc.utah.edu.
Mahiul M K MuqitVitreoretinal Service, Moorfields Eye Hospital NHS Trust, London, UK; Institute of Ophthalmology, University College London, UK. Electronic address: mahi.muqit1@nhs.net.
Daniel L RathbunDetroit Institute of Ophthalmology, Henry Ford Health System, Detroit, MI, USA; Center for Ophthalmology, University of Tüebingen, Tüebingen, Germany. Electronic address: DRathbu2@hfhs.org.
Katarina StinglCenter for Ophthalmology, University of Tüebingen, Tüebingen, Germany. Electronic address: katarina.stingl@med.uni-tuebingen.de.
James D WeilandDepartment of Biomedical Engineering and Department of Ophthalmology, University of Michigan, Ann Arbor, MI, USA. Electronic address: weiland@umich.edu.
Matthew A PetoeBionics Institute, East Melbourne, VIC, Australia; Department of Medical Bionics, The University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address: MPetoe@bionicsinstitute.org.
Australian National University · AUBionics Institute · AUHenry Ford Health System · USJohns Hopkins University · USMoorfields Eye Hospital NHS Foundation Trust · GBOsaka Health Science University · JPPixium Vision (France) · FRStanford University · USSTZ eyetrial · DEThe University of Melbourne · AUUniversity of Michigan · USUniversity of Utah · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2005 to 2026
$14.6M
Retinal RemodelingR01EY015128 · NEI · UNIVERSITY OF UTAH · PI JONES, BRYAN WILLIAM · 2004 to 2021
$7.0M
Retinal CircuitryR01EY028927 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bryan William Jones · 2019 to 2026
$5.2M
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY015128NEI NIH HHS R01 EY028927
6 · The paper itself

Abstract

Retinal prostheses are designed to restore a basic sense of sight to people with profound vision loss. They require a relatively intact posterior visual pathway (optic nerve, lateral geniculate nucleus and visual cortex). Retinal implants are options for people with severe stages of retinal degenerative disease such as retinitis pigmentosa and age-related macular degeneration. There have now been three regulatory-approved retinal prostheses. Over five hundred patients have been implanted globally over the past 15 years. Devices generally provide an improved ability to localize high-contrast objects, navigate, and perform basic orientation tasks. Adverse events have included conjunctival erosion, retinal detachment, loss of light perception, and the need for revision surgery, but are rare. There are also specific device risks, including overstimulation (which could cause damage to the retina) or delamination of implanted components, but these are very unlikely. Current challenges include how to improve visual acuity, enlarge the field-of-view, and reduce a complex visual scene to its most salient components through image processing. This review encompasses the work of over 40 individual research groups who have built devices, developed stimulation strategies, or investigated the basic physiology underpinning retinal prostheses. Current technologies are summarized, along with future challenges that face the field.

Indexed as

Visual ProsthesisHumansRetinitis PigmentosaTreatment OutcomeVision DisordersOphthalmologyRetinal diseaseRetinal prosthesisVision restoration

Identifiers

PMID31866339
PMCPMC7198351
OpenAlexW2994736635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.