Evidence map›Paper›PMID 31866224›Full record

ArticleCell stem cell2020

AXIN2

Tianliang Sun, Monika Pikiolek, Vanessa Orsini, Sebastian Bergling, Sjoerd Holwerda, Lapo Morelli, Philipp S Hoppe, Lara Planas-Paz, Yi Yang, Heinz Ruffner and 6 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
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  17. [Biological characteristics of liver zonation and its role in disease and aging].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  18. Article
  19. Influencing factors and mechanism of hepatocyte regeneration.Journal of translational medicine · 2025
    Review
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Tianliang SunNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Monika PikiolekNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Vanessa OrsiniNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Sebastian BerglingNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Sjoerd HolwerdaNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Lapo MorelliNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Philipp S HoppeNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Lara Planas-PazNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Yi YangNovartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA.
Heinz RuffnerNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Tewis BouwmeesterNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Felix LohmannNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Luigi M TerraccianoInstitute for Pathology, University Hospital Basel, Basel, Switzerland.
Guglielmo RomaNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Feng CongNovartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA.
Jan S TchorzNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address: jan.tchorz@novartis.com.
Novartis (Switzerland) · CHNovartis (United States) · USUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The existence of specialized liver stem cell populations, including AXIN2

Indexed as

HepatocytesLiverAnimalsAxin ProteinHomeostasisLiver RegenerationMiceStem CellsAxin2 protein, mouseAxin ProteinAXIN2LGR5liver homeostasisliver injuryliver regenerationliver stem cellmetabolic zonationpericentral hepatocyte nicheWnt signaling

Identifiers

PMID31866224
OpenAlexW2996106944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.