Evidence map›Paper›PMID 31866184›Full record

ReviewTrends in parasitology2020

Hardly Vacuous: The Parasitophorous Vacuolar Membrane of Malaria Parasites.

Daniel E Goldberg, Joshua Zimmerberg

Open access · hybridAbstract readReview
In one paragraph

Review in Trends in parasitology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. mBio · 2026
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  9. Intracellular Pathogens: Infection, Immunity, and Intervention.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: dgoldberg@wustl.edu.
Joshua ZimmerbergSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: zimmerbj@mail.nih.gov.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USWashington University in St. Louis · US

Funding

Membrane Remodeling in Viral Infection, Parasite Replication, and Traumatic Brain InjuryZIAHD001409 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ZIMMERBERG, JOSHUA · 2009 to 2025
$29.9M
PLASMEPSIN V FUNCTION IN MALARIA PARASITESR01AI047798 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2000 to 2015
$2.6M
IDENTIFICATION OF THE ANTIMALARIAL TARGET OF PEPSTATIN ESTERSR01AI112508 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI047798NIAID NIH HHS R01 AI112508
6 · The paper itself

Abstract

When a malaria parasite invades a host erythrocyte it pushes itself in and invaginates a portion of the host membrane, thereby sealing itself inside and establishing itself in the resulting vacuole. The parasitophorous vacuolar membrane (PVM) that surrounds the parasite is modified by the parasite, using its secretory organelles. To survive within this enveloping membrane, the organism must take in nutrients, secrete wastes, export proteins into the host cell, and eventually egress. Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining questions.

Indexed as

ErythrocytesHost-Parasite InteractionsHumansMalariaPlasmodiumVacuolesparasitophorous vacuolePlasmodium

Identifiers

PMID31866184
PMCPMC6937376
OpenAlexW2996235972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.