Trial reportThe Journal of allergy and clinical immunology2020
Reduction in mouse allergen exposure is associated with greater lung function growth.
Trial report in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Comprehensive home environmental intervention did not reduce allergen concentrations or controller medication requirements among children in Baltimore.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Trial
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
- Advancing equity in allergy and immunology: progress, pitfalls, and the path forward.Frontiers in allergy · 2025Review
- Minimizing Indoor Allergen Exposure: What Works?Current allergy and asthma reports · 2024Review
- Relationships between lung function, allergy, and wheezing in urban children.The Journal of allergy and clinical immunology · 2024Article
- Impact of socioeconomic factors on allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Effects of different inhalant allergens on lung functions in adult patients with bronchial asthma.Immunity, inflammation and disease · 2023Article
- Indoor Environmental Exposures and Their Relationship to Allergic Diseases.The journal of allergy and clinical immunology. In practice · 2023Article
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Environmental allergen reduction in asthma management: an overview.Frontiers in allergy · 2023Review
- Update on indoor allergens and their impact on pediatric asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- The influence of urban exposures and residence on childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- The role of environmental allergen control in the management of asthma.The World Allergy Organization journal · 2022Review
- Home Dust Allergen Exposure Is Associated with Outcomes among Sensitized Individuals with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Observational
- Asthma and the social determinants of health.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- 2020 Updated Asthma Guidelines: Indoor allergen reduction.The Journal of allergy and clinical immunology · 2020Article
- Indoor Air Pollution and Respiratory Health.Clinics in chest medicine · 2020Review
- Material Hardship and Indoor Allergen Exposure among Low-Income, Urban, Minority Children with Persistent Asthma.Journal of community health · 2020Article
- Childhood Origins of Adult Lung Disease as Opportunities for Prevention.The journal of allergy and clinical immunology. In practice · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundCurrent childhood asthma therapies have little effect on lung function trajectory.
objectiveWe sought to determine whether mouse allergen exposure reduction is associated with lung function growth in mouse-sensitized/exposed asthmatic children.
methodsThree hundred fifty mouse-sensitized/exposed asthmatic children (5-17 years old) were enrolled in a 1-year randomized trial of integrated pest management plus education versus education alone. Prebronchodilator/postbronchodilator spirometry was performed at baseline and 6 and 12 months, and bedroom floor mouse allergen levels were measured every 3 months. Mouse allergen reduction was defined as a 75% or greater decrease in mouse allergen levels from baseline. Treatment groups were combined for analyses because there were no differences in outcomes between groups. Changes in lung function over time were modeled, adjusting for age, sex, race, atopy, group, and bronchodilator reversibility and including an interaction term (allergen reduction*time).
resultsThe study population was predominantly black (79.4%) and low income (66.3% [<$30,000]). At baseline, the median mouse allergen level was 5.7 μg/g (interquartile range, 1.5-22.8 μg/g), and the mean (SD) prebronchodilator FEV
conclusionMouse allergen reduction is associated with greater increases in prebronchodilator FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.