Evidence map›Paper›PMID 31866091›Full record

ArticleNeuron2020

Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.

Yang Suo, Zilong Wang, Lejla Zubcevic, Allen L Hsu, Qianru He, Mario J Borgnia, Ru-Rong Ji, Seok-Yong Lee

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 128 citations in OpenAlex.

  1. Trial
  2. Sesquiterpene Lactone Derivatives ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Europium Metal Complex [Eu(dbm)Chemistry & biodiversity · 2026
    Article
  5. Curcumin Between Pleiotropic Potential and Translational Constraints.International journal of molecular sciences · 2026
    Review
  6. Article
  7. TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.International journal of molecular sciences · 2025
    Article
  12. Review
  13. The science of minerality.RSC advances · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Molecular basis of the urate transporter URAT1 inhibition by gout drugs.bioRxiv : the preprint server for biology · 2024
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yang SuoDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Zilong WangCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Lejla ZubcevicDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Allen L HsuGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Qianru HeCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Mario J BorgniaDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Ru-Rong JiCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Seok-Yong LeeDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: seok-yong.lee@duke.edu.
Duke University · USNational Institutes of Health · US

Funding

NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
Neuronal and glial interactions of neuropathic painR01DE017794 · NIDCR · DUKE UNIVERSITY · PI BUCHHEIT, THOMAS · 2006 to 2021
$6.6M
Structure, function, and pharmacology of neuronal membrane transport proteinsR35NS097241 · NINDS · DUKE UNIVERSITY · PI LEE, SEOK-YONG · 2016 to 2023
$6.1M
Intramural NIH HHS ZIC ES103326NIDCR NIH HHS R01 DE017794NINDS NIH HHS R35 NS097241
6 · The paper itself

Abstract

Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca

Indexed as

AcetamidesCryoelectron MicroscopyCysteineHEK293 CellsHumansIrritantsIsothiocyanatesModels, MolecularNociceptorsPainPatch-Clamp TechniquesPhospholipidsProtein DomainsProtein Structure, TertiaryPruritusThiazolesAcetamidesbenzyl isothiocyanateCysteineIrritantsIsothiocyanatesJT010PhospholipidsThiazolesTRPA1 Cation ChannelTRPA1 protein, humancovalent agonistcryo-EMcysteine modificationion channelItchPainreactive cysteineSensory neuronsTRPA1TRP channel

Identifiers

PMID31866091
PMCPMC7205012
OpenAlexW2995394720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.