Evidence map›Paper›PMID 31866066›Full record

ArticleCell2020

Structure of the Cardiac Sodium Channel.

Daohua Jiang, Hui Shi, Lige Tonggu, Tamer M Gamal El-Din, Michael J Lenaeus, Yan Zhao, Craig Yoshioka, Ning Zheng, William A Catterall

Open access · bronzeAbstract read
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 336 citations in OpenAlex.

  1. Late IMedicinal research reviews · 2026
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  12. Discovery of a novel NaActa pharmacologica Sinica · 2026
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  15. Hypokalaemia and bradycardia unmask the loss-of-function phenotype of a Brugada Syndrome SCN5A mutation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  16. Calcium interaction with Nav1.5 via FGF12A and CaM binding.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Review
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  20. Article

144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Daohua JiangDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Hui ShiDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Lige TongguDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Michael J LenaeusDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA; Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Yan ZhaoVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Craig YoshiokaVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address: nzheng@uw.edu.
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: wcatt@uw.edu.
University of Washington · USHoward Hughes Medical Institute · USOregon Health & Science University · USVollum Institute · US

Funding

Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
The Structural Basis of Antiarrhythmic Drug Binding in Voltage-gated Ion ChannelsK08HL145630 · NHLBI · UNIVERSITY OF WASHINGTON · PI LENAEUS, MICHAEL J · 2019 to 2023
$816k
Howard Hughes Medical InstituteNHLBI NIH HHS K08 HL145630NHLBI NIH HHS R01 HL112808
6 · The paper itself

Abstract

Voltage-gated sodium channel Na

Indexed as

AnimalsCell LineHeartHEK293 CellsHumansIon Channel GatingMembrane PotentialsNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesRatsSodiumSodium ChannelsStructure-Activity RelationshipVoltage-Gated Sodium ChannelsNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, ratSodiumSodium ChannelsVoltage-Gated Sodium Channelsantiarrhytymic drugscryoelectron microscopy arrhythmiafast inactivationgating pore currentheartsodium channelsodium selectivity

Identifiers

PMID31866066
PMCPMC6986426
OpenAlexW2995985288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.