ArticleFluids and barriers of the CNS2019
Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus.
Article in Fluids and barriers of the CNS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Comprehensive review of the cerebral aqueduct: anatomy, embryology, imaging, genetics, molecular, and pathology.Anatomy & cell biology · 2026Review
- Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults.Journal of magnetic resonance imaging : JMRI · 2026Article
- Deformation of brain in normal pressure hydrocephalus is more readily associated with slow vasomotion rather than heartbeat related pulsations of intracranial pressure.Fluids and barriers of the CNS · 2025Article
- Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults.Fluids and barriers of the CNS · 2025Article
- Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate.Brain multiphysics · 2024Article
- An In-Vitro Experimental Investigation of Oscillatory Flow in the Cerebral Aqueduct.Research square · 2023Article
- Hydrocephalus: historical analysis and considerations for treatment.European journal of medical research · 2022Review
- Transmantle and transvenous pressure gradients in cerebrospinal fluid disorders.Neurosurgical review · 2022Review
- Article
- AnEuropean journal of mechanics. B, FluidsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCommunicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF pulsatility measured in the cerebral aqueduct (CA). We hypothesize that the cardiac-related pulsatile flow over the CA, with fast systolic outflow and slow diastolic inflow, can generate net pressure effects that could source the ventriculomegaly in these patients. This would require a non-zero cardiac cycle averaged net pressure difference (ΔP
methodsWe tested the hypothesis by calculating ΔP
resultsThe ΔP
conclusionsThe results supported the hypothesis with respect to the direction of ΔP
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.