Evidence map›Paper›PMID 31865795›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Influence of Genetic Variation in

Matthew Traylor, Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D Anderson and 2 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Matthew TraylorFrom the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).
Ali Amin Al OlamaFrom the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
Sandro MariniCenter for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Jaeyoon ChungCenter for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Rainer MalikInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany (R.M., M.D.).
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Germany (R.M., M.D.).
Mika KähönenDepartment of Clinical Physiology (M.K.), Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
Christopher D AndersonCenter for Genomic Medicine, Massachusetts General Hospital, Boston (S.M., J.C., C.D.A.).
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.).
Hugh S MarkusFrom the Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., A.A.A.O., H.S.M.).
Massachusetts General Hospital · USTampere University · FIUniversity of Cambridge · GBBroad Institute · USFimlab (Finland) · FILudwig-Maximilians-Universität München · DEMunich Cluster for Systems Neurology · DETurku University Hospital · FIWilliam Harvey Research Institute · GB

Funding

Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Genetic Analyses of Lipids in Cerebral Hemorrhage and Small Vessel DiseaseK23NS086873 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2014 to 2018
$951k
British Heart Foundation RG/16/4/32218Medical Research Council 102215/2/13/2Medical Research Council G9521010Medical Research Council G9815508Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MR/M009203/1NINDS NIH HHS K23 NS086873NINDS NIH HHS R01 NS103924
6 · The paper itself

Abstract

We aimed to characterize the genetics of endothelial function and how this influences risk for cardiovascular diseases such as ischemic stroke. We integrated genetic data from a study of ultrasound flow-mediated dilatation of brachial artery in adolescents from ALSPAC (Avon Longitudinal Study of Parents and Children; n=5214) with a study of ischemic stroke (MEGASTROKE: n=60 341 cases and 452 969 controls) to identify variants that confer risk of ischemic stroke through altered endothelial function. We identified a variant in

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdolescentAdultBrain IschemiaChildCyclic Nucleotide Phosphodiesterases, Type 3Endothelium, VascularFemaleFollow-Up StudiesGenetic VariationHumansHypertensionMaleMiddle AgedPregnancyCyclic Nucleotide Phosphodiesterases, Type 3PDE3A protein, humancyclic nucleotide phosphodiesterases, type 3geneticsgenome-wide association studystrokevascular endothelium

Identifiers

PMID31865795
PMCPMC7055937
OpenAlexW2996666693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.