Evidence map›Paper›PMID 31865783›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Inhibition of AT2R and Bradykinin Type II Receptor (BK2R) Compromises High K

Li Gu, JunLin Wang, Dan-Dan Zhang, XinXin Meng, YunHong Zhang, JiaWen Zhang, Hao Zhang, XiWen Guo, Dao-Hong Lin, Wen-Hui Wang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Li GuFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
JunLin WangFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
Dan-Dan ZhangDepartment of Pharmacology, New York Medical College, Valhalla (D.-D. Z., D.-H.L, W.-H.W.).
XinXin MengFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
YunHong ZhangFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
JiaWen ZhangFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
Hao ZhangFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
XiWen GuoFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla (D.-D. Z., D.-H.L, W.-H.W.).
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla (D.-D. Z., D.-H.L, W.-H.W.).
Rui-Min GuFrom the Department of Physiology, Harbin Medical University, China (L.G., J.W., X.M., Y.Z, J.Z., H.Z., X.G., R.-M.G.).
Harbin Medical University · CNNew York Medical College · US

Funding

Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Kir5.1 regulates Kir4.1 ubiquitination by Nedd4-2 in DCTR01DK115366 · NIDDK · NEW YORK MEDICAL COLLEGE · PI LIN, DAO-HONG · 2018 to 2021
$1.5M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK115366NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

The inhibition of Type II angiotensin II receptor (AT2R) or BK2R (bradykinin type II receptor) stimulates basolateral Kir4.1/Kir5.1 in the distal convoluted tubule (DCT) and activates thiazide-sensitive NCC (Na-Cl cotransporter). The aim of the present study is to examine the role of AT2R and BK2R in mediating the effect of HK (high dietary K

Indexed as

AnimalsBiological TransportDisease Models, AnimalFemaleHyperkalemiaImmunoblottingKidney Tubules, DistalMaleMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutPotassiumReceptor, Bradykinin B2Receptors, AngiotensinPotassiumReceptor, Bradykinin B2Receptors, Angiotensinhydrochlorothiazidenatriuresisreceptorsthiazides

Identifiers

PMID31865783
PMCPMC7561014
OpenAlexW2997205400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.