ArticleHypertension (Dallas, Tex. : 1979)2020
Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
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Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- Conditional ablation of RGS2 in myeloid cells does not influence blood pressure and organ damage in angiotensin II-induced hypertension in mice.Physiological reports · 2026Article
- Cardiovascular complications of pregnancy.The Journal of clinical investigation · 2026Review
- Role of ubiquitin‑proteasome system in preeclampsia (Review).Molecular medicine reports · 2026Review
- The multifactorial role of HDAC9 at the maternal-fetal interface in the pathogenesis of preeclampsia.Clinical science (London, England : 1979) · 2025Review
- Localization and quantification of placentalPhysiological genomics · 2025Article
- Article
- Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.Physiological genomics · 2024Article
- KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation.bioRxiv : the preprint server for biology · 2024Article
- Phosphodiesterases Mediate the Augmentation of Myogenic Constriction by Inhibitory G Protein Signaling and is Negatively Modulated by the Dual Action of RGS2 and 5.Function (Oxford, England) · 2024Article
- Effects of regulator of G protein signaling 2 (RGS2) overexpression in the paraventricular nucleus on blood pressure in rats with angiotensin II-induced hypertension.Frontiers in physiology · 2024Article
- Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling.Science advances · 2023Article
- RGS2 and female common diseases: a guard of women's health.Journal of translational medicine · 2023Review
- Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum.Scientific reports · 2023Article
- RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy.Experimental & molecular medicine · 2023Article
- Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Hypertension (Dallas, Tex. : 1979) · 2022Article
- Low-dose aspirin inhibits trophoblast cell apoptosis by activating the CREB/Bcl-2 pathway in pre-eclampsia.Cell cycle (Georgetown, Tex.) · 2022Article
- Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.Nature communications · 2022Article
- Animal Models of Cardiovascular Complications of Pregnancy.Circulation research · 2022Review
- Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction.Molecular metabolism · 2022Article
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Authors and funding
20 authors at 3 institutions in 1 country.
Katherine J PerschbacherFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Guorui DengFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Jeremy A SandgrenFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
John W WalshFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Phillip C WitcherFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Sarah A SapouckeyFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Caitlyn E OwensFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Shao Yang ZhangFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Sabrina M ScrogginsDepartment of Obstetrics and Gynecology (S.M.S., E.J.D., D.A.S., M.K.S.), University of Iowa, Iowa City.
Nicole A PearsonFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Eric J DevorDepartment of Obstetrics and Gynecology (S.M.S., E.J.D., D.A.S., M.K.S.), University of Iowa, Iowa City.
Julien A SebagDepartment of Physiology (J.A.S.), University of Iowa, Iowa City.
Gary L PierceDepartment of Health and Human Physiology (G.L.P.), University of Iowa, Iowa City.
Rory A FisherFrom the Department of Pharmacology (K.J.P., G.D., J.A.S., J.W.W., P.C.W., S.A.S., C.E.O., S.Y.Z., N.A.P., R.A.F.), University of Iowa, Iowa City.
Anne E KwitekDepartment of Physiology (A.E.K., C.D.S., J.L.G.), Medical College of Wisconsin, Milwaukee.
Donna A SantillanDepartment of Obstetrics and Gynecology (S.M.S., E.J.D., D.A.S., M.K.S.), University of Iowa, Iowa City.
Katherine N Gibson-CorleyDepartment of Pathology (K.N.G.-C.), University of Iowa, Iowa City.
Curt D SigmundDepartment of Physiology (A.E.K., C.D.S., J.L.G.), Medical College of Wisconsin, Milwaukee.
Mark K SantillanDepartment of Obstetrics and Gynecology (S.M.S., E.J.D., D.A.S., M.K.S.), University of Iowa, Iowa City.
Justin L GrobeDepartment of Physiology (A.E.K., C.D.S., J.L.G.), Medical College of Wisconsin, Milwaukee.
University of Iowa · USPearson (United States) · USWalsh University · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0MRole of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2MThe University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MMedical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7MPPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MSHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3MRole of Enhancers Regulating Renin Gene ExpressionR37HL048058 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2006 to 2015
$4.3MVasopressin and Preeclampsia: Early Mechanisms for PreventionR01HD089940 · NICHD · UNIVERSITY OF IOWA · PI SANTILLAN, MARK K · 2019 to 2023
$1.9MNCATS NIH HHS UL1 TR002537NCI NIH HHS P30 CA086862NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R35 HL144807NHLBI NIH HHS R37 HL048058NHLBI NIH HHS T35 HL007485NICHD NIH HHS R01 HD089940NIGMS NIH HHS T32 GM007337NIGMS NIH HHS T32 GM063483
Abstract
Cascade-specific termination of G protein signaling is catalyzed by the RGS (regulator of G protein signaling) family members, including
Indexed as
Gene Expression RegulationPregnancy, AnimalAnimalsDisease Models, AnimalDisease ProgressionFemaleHumansMiceMice, Inbred C57BLPlacentaPre-EclampsiaPregnancyRGS ProteinsRNA, MessengerSignal TransductionRGS2 protein, humanRGS ProteinsRNA, MessengerGTP-binding proteinshypertensionplacentapreeclampsiapregnancy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.