Evidence map›Paper›PMID 31865615›Full record

ArticleNMR in biomedicine2022

Arterial spin labeling MR image denoising and reconstruction using unsupervised deep learning.

Kuang Gong, Paul Han, Georges El Fakhri, Chao Ma, Quanzheng Li

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  7. Improved accuracy for myocardial blood flow mapping with deep learning-enabled CMR arterial spin labeling (DeepMASL): Validation by microsphere in vivo.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kuang GongGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2669-2610
Paul HanGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1650-1347
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Chao MaGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Quanzheng LiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
Quantitative Oncologic PET-MRR01CA165221 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2012 to 2023
$4.7M
Postgraduate Training Program in Medical Imaging (PTPMI)T32EB013180 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Ciprian Catana, Pedram Heidari · 2011 to 2026
$3.7M
PET/MR Mapping of Myocardial Membrane PotentialR01HL137230 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2017 to 2020
$3.3M
Methods for Quantitative Neuroimaging of Tau Burden inPre-symptomatic ADR01AG076153 · NIA · YALE UNIVERSITY · PI Georges El Fakhri, Marc David Normandin · 2022 to 2026
$3.0M
Quantitative Simultaneous Cardiac PET-MRR01HL118261 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI OUYANG, JINSONG · 2014 to 2018
$2.6M
Study of Brain Spreading Pathways of Tau and Amyloid-Beta in (pre)clinical ADRF1AG052653 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LI, QUANZHENG, SEPULCRE, JORGE · 2017 to 2017
$1.4M
NCI NIH HHS R01 CA165221NHLBI NIH HHS R01 HL118261NHLBI NIH HHS R01 HL137230NIA NIH HHS R01 AG076153NIA NIH HHS RF1 AG052653NIBIB NIH HHS P41 EB022544NIBIB NIH HHS T32 EB013180
6 · The paper itself

Abstract

Arterial spin labeling (ASL) imaging is a powerful magnetic resonance imaging technique that allows to quantitatively measure blood perfusion non-invasively, which has great potential for assessing tissue viability in various clinical settings. However, the clinical applications of ASL are currently limited by its low signal-to-noise ratio (SNR), limited spatial resolution, and long imaging time. In this work, we propose an unsupervised deep learning-based image denoising and reconstruction framework to improve the SNR and accelerate the imaging speed of high resolution ASL imaging. The unique feature of the proposed framework is that it does not require any prior training pairs but only the subject's own anatomical prior, such as T1-weighted images, as network input. The neural network was trained from scratch in the denoising or reconstruction process, with noisy images or sparely sampled k-space data as training labels. Performance of the proposed method was evaluated using in vivo experiment data obtained from 3 healthy subjects on a 3T MR scanner, using ASL images acquired with 44-min acquisition time as the ground truth. Both qualitative and quantitative analyses demonstrate the superior performance of the proposed txtc framework over the reference methods. In summary, our proposed unsupervised deep learning-based denoising and reconstruction framework can improve the image quality and accelerate the imaging speed of ASL imaging.

Indexed as

Deep LearningBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingSignal-To-Noise RatioSpin LabelsSpin Labelsapplicationshuman studymethods and engineeringneurologicalperfusion and permeability methodsperfusion spin labeling methodspost-acquisition processingreconstruction

Identifiers

PMID31865615
PMCPMC7306418
OpenAlexW2995273252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.