Evidence map›Paper›PMID 31865537›Full record

ArticleTropical animal health and production2020

Efficacy of VERYL® in the treatment of cattle naturally infected with gastro-intestinal nematodes in Kenya.

M W Maichomo, J M Nginyi, A Caruso-Varès, E O Mungube, G Pagny, C Chevtzoff, J C Njanja, P A Lumumba, J F Collin, N Isaka

Abstract readClinical Trial, Veterinary
PubMed Publisher
In one paragraph

Article in Tropical animal health and production, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

M W MaichomoKenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya. monicah.maichomo@kalro.org.ORCID http://orcid.org/0000-0001-6091-1437
J M NginyiKenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
A Caruso-VarèsCeva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
E O MungubeKenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
G PagnyCeva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
C ChevtzoffCeva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
J C NjanjaKenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
P A LumumbaKenya Agricultural & Livestock Research Organization (KALRO), Veterinary Research Institute, Muguga North, P.O. Box 32-00902, Kikuyu, Kenya.
J F CollinCeva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
N IsakaCeva Santé Animale, 10 av. de La Ballastière, 33500, Libourne, France.
Département Santé Animale · FRKenya Agricultural and Livestock Research Organization · KE

Funding

Ceva Sante Animale CLT/C753/1514
6 · The paper itself

Abstract

Co-infections caused by trypanosomes and gastro-intestinal nematodes (GINs) compromise cattle productivity and their control requires a holistic approach. The effectiveness of trypanocides and anthelmintics is compromised by increasing resistance. Use of combined chemotherapeutic products for synergy, mainly practiced in human medicine, is gaining importance in livestock. A trial to evaluate efficacy of VERYL®, containing diminazene diaceturate (3.5 mg/kg body weight) and levamisole chloride (5 mg/kg body weight) for the control of GINs in cattle, was conducted at KALRO-VSRI Muguga, Kenya, between June and August 2016. Thirty-eight cattle aged between 6 and 12 months, naturally infected with GINs, were randomly allocated into two groups; a treatment group received VERYL® intra-muscularly at 10 mL/100 kg bwt and a control group which received Veriben® (Diminazene aceturate) at 3.5 mg/kg bwt. Faecal egg counts (FECs), coproculture, packed cell volume (PCV) and local tolerance at the injection site were measured during the study. FECs were comparable between the treatment and control groups at day 0. However, treatment of cattle with VERYL significantly (p < 0.001) reduced FECs by day 7 and sustained to day 21 post-treatment. Coproculture results for the treatment and control groups revealed presence of Haemonchus, Cooperia, Ostertagia, Trichostrongylus and Oesophagostomum species. Cattle treated with VERYL® had a significant (p < 0.05) reduction in larval recoveries compared to the control group. VERYL® had minimal adverse effects which cleared after a short while and is thus recommended for controlling GINs in cattle.

Indexed as

AnimalsAnthelminticsCattleCattle DiseasesDiminazeneFecesHaemonchusKenyaLevamisoleNematode InfectionsParasite Egg CountRandom AllocationTrichostrongylusAnthelminticsDiminazenediminazene aceturateLevamisoleEfficacyFaecal egg countsHelminths

Identifiers

PMID31865537
OpenAlexW2994868414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.