ArticleGeroScience2020
Magnetic resonance elastography (MRE) shows significant reduction of thigh muscle stiffness in healthy older adults.
Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Muscle elasticity variations in assessing age-related changes in adults - A systematic review.Geriatrics & gerontology international · 2025Pooled it
- Position dependent elasticity of the anterior talofibular ligament in healthy young women: an in-vivo shear wave elastography study.European journal of applied physiology · 2026Article
- Quantification of muscle morphology and stiffness in spastic hemiplegic cerebral palsy versus typically developing controls using magnetic resonance elastography.Clinical biomechanics (Bristol, Avon) · 2026Article
- Shear wave elastography for assessing rectus femoris stiffness: a study on the interaction and reliability of body position and contraction state.Frontiers in bioengineering and biotechnology · 2026Article
- Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Test-retest reliability and follow-up of muscle magnetic resonance elastography in adults with and without muscle diseases.Journal of cachexia, sarcopenia and muscle · 2024Article
- MR elastography-based slip interface imaging (SII) for functional assessment of myofascial interfaces: A feasibility study.Magnetic resonance in medicine · 2024Article
- Hamstring Muscle Stiffness in Athletes with and without Anterior Cruciate Ligament Reconstruction History: A Retrospective Study.Journal of clinical medicine · 2024Article
- Post-mortem changes of anisotropic mechanical properties in the porcine brain assessed by MR elastography.Brain multiphysics · 2024Article
- Shear wave speeds in a nearly incompressible fibrous material with two unequal fiber families.The Journal of the Acoustical Society of America · 2024Article
- Article
- Objective Methods of Muscle Tone Diagnosis and Their Application-A Critical Review.Sensors (Basel, Switzerland) · 2023Review
- Human skeletal muscle-specific atrophy with aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Article
- Reliability of Gradient-Echo Magnetic Resonance Elastography of Lumbar Muscles: Phantom and Clinical Studies.Diagnostics (Basel, Switzerland) · 2022Article
- Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes.Current protocols · 2022Article
- Ultrasound shear wave elastography of the anterior talofibular and calcaneofibular ligaments in healthy subjects.Journal of ultrasonography · 2021Article
- MRI of myositis and other urgent muscle-related disorders.Emergency radiology · 2021Review
- Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading.GeroScience · 2021Article
- Shear wave speeds in nearly-incompressible fibrous materials with two fiber families.The Journal of the Acoustical Society of America · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Determining the effect of ageing on thigh muscle stiffness using magnetic resonance elastography (MRE) and investigate whether fat fraction and muscle cross-sectional area (CSA) are related to stiffness. Six healthy older adults in their eighth and ninth decade and eight healthy young men were recruited and underwent a 3 T MRI protocol including MRE and Dixon fat fraction imaging. Muscle stiffness, fat fraction and muscle CSA were calculated in ROIs corresponding to the four quadriceps muscles (i.e. vastus lateralis (VL), vastus medialis (VM), vastus intermedius (VI), rectus femoris (RF)), combined quadriceps, combined hamstrings and adductors and whole thigh. Muscle stiffness was significantly reduced (p < 0.05) in the older group in all measured ROIs except the VI (p = 0.573) and RF (p = 0.081). Similarly, mean fat fraction was significantly increased (p < 0.05) in the older group over all ROIs with the exception of the VI (p = 0.059) and VL muscle groups (p = 0.142). Muscle CSA was significantly reduced in older participants in the VM (p = 0.003) and the combined quadriceps (p = 0.001), hamstrings and adductors (p = 0.008) and whole thigh (p = 0.003). Over the whole thigh, stiffness was significantly negatively correlated with fat fraction (r = - 0.560, p = 0.037) and positively correlated with CSA (r = 0.749, p = 0.002). Stepwise regression analysis revealed that age was the most significant predictor of muscle stiffness (p = 0.001). These results suggest that muscle stiffness is significantly decreased in healthy older adults. Muscle fat fraction and muscle CSA are also significantly changed in older adults; however, age is the most significant predictor of muscle stiffness.
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Registered trials
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