Evidence map›Paper›PMID 31865501›Full record

ArticleCellular and molecular neurobiology2020

Progesterone Protects Prefrontal Cortex in Rat Model of Permanent Bilateral Common Carotid Occlusion via Progesterone Receptors and Akt/Erk/eNOS.

Miloš Stanojlović, Ivana Guševac Stojanović, Marina Zarić, Jelena Martinović, Nataša Mitrović, Ivana Grković, Dunja Drakulić

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Progesterone activation of βNature communications · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Miloš Stanojlović *Department of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Ivana Guševac Stojanović *Department of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Marina ZarićDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Jelena MartinovićDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Nataša MitrovićDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Ivana GrkovićDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia.
Dunja DrakulićDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade, 11001, Republic of Serbia. drakulic@vinca.rs.ORCID http://orcid.org/0000-0003-1448-9639
University of Belgrade · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 173044Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 41014
6 · The paper itself

Abstract

Sustained activation of pro-apoptotic signaling due to a sudden and prolonged disturbance of cerebral blood circulation governs the neurodegenerative processes in prefrontal cortex (PFC) of rats whose common carotid arteries are permanently occluded. The adequate neuroprotective therapy should minimize the activation of toxicity pathways and increase the activity of endogenous protective mechanisms. Several neuroprotectants have been proposed, including progesterone (P

Indexed as

AnimalsCarotid Artery, CommonCarotid StenosisDNA FragmentationExtracellular Signal-Regulated MAP KinasesMaleNeuronsNeuroprotective AgentsNitric Oxide Synthase Type IIIPrefrontal CortexProgesteroneProto-Oncogene Proteins c-aktRatsRats, WistarReceptors, ProgesteroneSignal Transduction4-pregnene-3,20-dioneExtracellular Signal-Regulated MAP KinasesNeuroprotective AgentsNitric Oxide Synthase Type IIINos3 protein, ratProgesteroneProto-Oncogene Proteins c-aktReceptors, ProgesteroneCerebral hypoperfusionNeuroprotectionPrefrontal cortexProgesterone

Identifiers

PMID31865501
PMCPMC11448933
OpenAlexW2995239810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.