Evidence map›Paper›PMID 31865497›Full record

ArticleThe international journal of cardiovascular imaging2020

Measurement errors in serial echocardiographic assessments of aortic valve stenosis severity.

Kalie Kebed, Deyu Sun, Karima Addetia, Victor Mor-Avi, Natasha Markuzon, Roberto M Lang

Open access · greenAbstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

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  8. Diagnostic Challenges in Aortic Stenosis.Journal of cardiovascular development and disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kalie KebedDepartment of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Deyu SunPhilips Healthcare, Andover, MA, USA.
Karima AddetiaDepartment of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Victor Mor-AviDepartment of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Natasha MarkuzonPhilips Healthcare, Andover, MA, USA.
Roberto M LangDepartment of Medicine, University of Chicago Medical Center, Chicago, IL, USA. rlang@medicine.bsd.uchicago.edu.
University of Chicago Medical Center · USPhilips (United States) · US

Funding

MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
NHLBI NIH HHS T32 HL007381
6 · The paper itself

Abstract

Transthoracic echocardiography (TTE) evaluation of aortic stenosis (AS) is routinely performed using the continuity equation. Inaccurate measurements of the left ventricular (LV) outflow tract (LVOT) diameter are considered the most common source of error in AS grading. We hypothesized that inconsistency in LVOT velocity time integral (VTI) is an under-recognized cause of AS assessment error. We sought to determine which parameters contribute most towards inconsistencies in AS grading by studying the prevalence of different errors in a historic cohort. We identified patients with mild to severe AS with multiple studies from our database from 1994 to 2018 (n = 988 patients, 2859 studies). Errors were defined when: (1) LVOT diameter changed by > 2 mm, (2) LVOT VTI changed by > 15% without change in LV function from the initial TTE, (3) aortic valve (AV) maximum velocity (Vmax), mean pressure gradient (ΔP) or AV VTI decreased by > 15% without change in LV function from prior study. The most common error was the LVOT VTI measurement with 22% prevalence. LVOT diameter, AV VTI, AV Vmax and AV ΔP measurement caused errors in < 7% studies. Patients with normal LV function and more severe AS were more likely to have LVOT VTI errors (P < 0.05). LVOT VTI is a frequent, under-recognized source of error in assessing AS. Greater attention should be directed toward the proper positioning of the pulsed Doppler sample volume, particularly in patients with higher grades of AS and normal systolic function, to ensure accurate and reproducible assessment of AS.

Indexed as

Echocardiography, Doppler, ColorEchocardiography, Doppler, PulsedAortic ValveAortic Valve StenosisDatabases, FactualHeart VentriclesHemodynamicsHumansPredictive Value of TestsPrognosisReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexTime FactorsVentricular Function, LeftAortic stenosisDoppler echocardiographyLeft ventricular outflow tractValvular heart disease

Identifiers

PMID31865497
PMCPMC7135919
OpenAlexW2995675359

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.