ArticleJournal of assisted reproduction and genetics2020
The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Interaction between triglyceride-glucose index and body mass index on pregnancy loss in Chinese women with polycystic ovary syndrome: a secondary analysis of a randomized clinical trial.Reproductive biology and endocrinology : RB&E · 2026Article
- Research progress on non-invasive testing of endometrial receptivity.Frontiers in reproductive health · 2026Review
- Extracellular Vesicles, Lipid Droplets and AhR Ligands in Early Implantation: The Dynamics of Embryo-Maternal Crosstalk.Journal of extracellular vesicles · 2025Article
- Investigation of Phosphatidylcholine by MALDI Imaging Mass Spectrometry in Normal and IVF Early-Stage Embryos.International journal of molecular sciences · 2024Article
- Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure.Human reproduction open · 2024Article
- Serum and follicular fluid metabolome and markers of ovarian stimulation.Human reproduction (Oxford, England) · 2023Article
- Lipid Changes in the Peri-Implantation Period with Mass Spectrometry Imaging: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility.Frontiers in endocrinology · 2023Article
- microRNA-based signatures obtained from endometrial fluid identify implantative endometrium.Human reproduction (Oxford, England) · 2022Article
- GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo characterize the most relevant changes in the lipidome of endometrial fluid aspirate (EFA) in non-implantative cycles.
designLipidomics in a prospective cohort study. SETTINGS: Reproductive unit of a university hospital. PATIENTS: Twenty-nine women undergoing an IVF cycle. Fifteen achieved pregnancy and 14 did not.
interventionEndometrial fluid aspiration immediately before performing embryo transfer.
main outcome measuresClinical pregnancy rate and lipidomic profiles obtained on an ultra-high performance liquid chromatography coupled to time-of-flight mass spectrometry (UHPLC-ToF-MS)-based analytical platform.
resultsThe comparative analysis of the lipidomic patterns of endometrial fluid in implantative and non-implantative IVF cycles revealed eight altered metabolites: seven glycerophospholipids and an omega-6 polyunsaturated fatty acid. Then, women with a non-implantative cycle were accurately classified with a support vector machine algorithm including these eight lipid metabolites. The diagnostic performances of the algorithm showed an area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy of 0.893 ± 0.07, 85.7%, 80.0%, and 82.8%, respectively.
conclusionA predictive lipidomic signature linked to the implantative status of the endometrial fluid has been found.
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