ArticleSurgery today2020
Early renal dysfunction after temporary ileostomy construction.
Article in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Overall readmissions and readmissions related to dehydration after creation of an ileostomy: a systematic review and meta-analysis.Techniques in coloproctology · 2022Pooled it
- Impact of Renin-Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study.Annals of gastroenterological surgery · 2026Article
- Article
- Protective ileostomy after low anterior resection for extraperitoneal rectal cancer: does the reversal surgery timing affect closure failure?Updates in surgery · 2023Article
- Analysis of factors associated with postoperative acute kidney injury in patients with colorectal cancer and the development of a risk prediction model: a retrospective study.Updates in surgery · 2023Article
- Defunctioning loop ileostomy in anterior resection for rectal cancer and subsequent renal failure: nationwide population-based study.BJS open · 2023Observational
- Temporary impairment of renal function in patients with rectal cancer treated with diverting ileostomy.Journal of gastrointestinal oncology · 2021Article
- Assessment of the risk of permanent stoma after low anterior resection in rectal cancer patients.World journal of surgical oncology · 2020Article
- Tolerability and Adverse Events of Adjuvant Chemotherapy for Rectal Cancer in Patients With Diverting Ileostomy.In vivo (Athens, Greece)Article
- Deterioration in renal function after stoma creation: a retrospective review from a Middle Eastern tertiary care center.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLoop ileostomy is often used to prevent complications after colorectal surgery, but it has been reported to cause renal impairment. This study aimed to evaluate the changes in the renal function after ileostomy and to compare these with the renal function after low anterior resection without ileostomy (low-ANT).
methodsThe subjects included 58 patients who underwent ileostomy construction and closure for rectal cancer. The estimated glomerular filtration rate (eGFR) was calculated at specific time points after the index surgery. In addition, we conducted a case-matched study on 147 patients who underwent low-ANT.
resultsThe eGFR was significantly lower at 1 month after ileostomy than at the time of ileostomy construction (78.8 vs. 84.0, p < 0.0001) and did not improve after ileostomy closure. The only risk factor for a reduced eGFR was preoperative chemotherapy or chemoradiotherapy. In the case-matched study, 36 patients were allocated for each of the two groups. The number of ileostomy patients with a reduced eGFR was significantly increased 1 month after the index surgery (p = 0.005).
conclusionsThe eGFR began to decrease at one month after ileostomy construction and did not improve after ileostomy closure.
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