Evidence map›Paper›PMID 31865435›Full record

ArticleInternational journal of colorectal disease2020

Colectomy with ileostomy for severe ulcerative colitis-postoperative complications and risk factors.

C Schineis, K S Lehmann, J C Lauscher, K Beyer, L Hartmann, G A Margonis, J Michel, C E Degro, F N Loch, F Speichinger and 2 more

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Influence of nutritional status in the postoperative period of patients with inflammatory bowel disease.World journal of gastrointestinal pharmacology and therapeutics · 2021
    Review
  4. Article
  5. Ulcerative colitis.Nature reviews. Disease primers · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

C SchineisDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. christian.schineis@charite.de.ORCID http://orcid.org/0000-0001-9189-6751
K S LehmannDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
J C LauscherDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
K BeyerDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
L HartmannDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
G A MargonisDepartment of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
J MichelDepartment of Pediatric Cardiology, Pulmology and Pediatric Intensive Care Medicine, University Children's Hospital Tübingen, Hoppe-Seyler-Straße 1, 72076, Tübingen, Germany.
C E DegroDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
F N LochDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
F SpeichingerDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
M E KreisDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
C KamphuesDepartment of General, Visceral and Vascular Surgery, Charité University Hospital Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEFranklin University · USJohns Hopkins University · USUniversity Children's Hospital Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn the era of biological therapy of ulcerative colitis (UC), surgical treatment frequently consists of colectomy, end ileostomy, and rectal stump closure before patients go on towards restorative proctocolectomy. We aimed to evaluate possible risk factors for the occurrence of postoperative complications and investigate those after initial colectomy in these patients.

methodsRetrospective analysis of 180 patients (76 female, 104 male) undergoing colectomy for UC with formation of a rectal stump and terminal ileostomy between March 2008 and March 2018 at Charité University Hospital Berlin, Campus Benjamin Franklin. A panel of possible postoperative complications was established, patient history was screened, and postoperative complications were analyzed using the Clavien Dindo Classification.

resultsPostoperative complication rate was 27.7%. Mortality was 0.5%. Postoperative ileus occurred in 15.3% and rectal stump leakage in 14.8%. Complications were categorized as Clavien Dindo 3 in 80%. Risk factors for surgical complications after multivariate analysis were ASA classification (p = 0.004), preoperative anemia (Hemoglobin < 8 mg/dl) (p = 0.025), use of immunosuppressants (p = 0.003), more than two cardiovascular diseases (p = 0.016), and peritonitis (p = 0.000). Reoperation rate of patients with surgical complications was 27.7%.

conclusionColectomy in high-risk UC patients is associated with significant morbidity. However, most of the surgical complications can be treated conservatively. Overall mortality is low. Patient-related risk factors are associated with postoperative complications. Optimizing these risk factors or earlier indication for surgery in the course of UC may help to reduce morbidity of this procedure.

Indexed as

AdolescentAdultAgedAged, 80 and overColectomyColitis, UlcerativeFemaleHumansIleostomyMaleMiddle AgedPostoperative ComplicationsRisk FactorsYoung AdultColectomyPostoperative complicationsRectal stump leakageUlcerative colitis

Identifiers

PMID31865435
OpenAlexW2996309957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.