Evidence map›Paper›PMID 31865423›Full record

Trial reportEuropean journal of nutrition2020

n-3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open study.

A Shabrina, T-H Tung, N T K Nguyen, H-C Lee, H-T Wu, W Wang, S-Y Huang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A ShabrinaSchool of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing Street, Taipei, 110, Taiwan.
T-H TungSchool of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing Street, Taipei, 110, Taiwan.
N T K NguyenSchool of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing Street, Taipei, 110, Taiwan.
H-C LeeSchool of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing Street, Taipei, 110, Taiwan.
H-T WuGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.
W WangGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.
S-Y HuangSchool of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing Street, Taipei, 110, Taiwan. sihuang@tmu.edu.tw.ORCID http://orcid.org/0000-0003-2914-5513
Taipei Medical University · TWTaipei Medical University Hospital · TW

Funding

Taiwan Ministry of Science and Technology of the People's Republic of China (CN) MOST106-2314-B-038-049Taiwan Ministry of Science and Technology of the People's Republic of China (CN) MOST106-2320-B-038-062-MY3
6 · The paper itself

Abstract

purposeFor people with metabolic syndrome (MetS), altering the macronutrient composition of their diets might ameliorate metabolic abnormalities. The common method of clinical assessment only measures total lipid concentrations but ignores the individual species that contribute to these total concentrations. Thus, to predict the amelioration of MetS following caloric restriction (CR) and the intake of fish oil, we used lipidomics to investigate changes in plasma lipids and identify potential lipid metabolites.

methodsLipidomics was performed using ultra-high-performance liquid chromatography-tandem mass spectrometry on plasma samples from a clinical trial conducted over 12 weeks. Subjects were randomized into two groups: CR (n = 12) and CR with fish oil (CRF, n = 9). Anthropometric and clinical parameters were measured and correlated with plasma lipidomics data.

resultsCompared with baseline, significant differences were observed in body weight, waist circumference, blood pressure and interleukin-6 in both groups, but triglyceride (TG) levels significantly decreased in only the CRF group (all p < 0.05). A total of 138 lipid species were identified. Levels of species containing long-chain polyunsaturated fatty acids were significantly elevated-greater than twofold-following fish oil intake, these included TG (60:9) and phosphatidylcholine (p40:6) (all q < 0.05). TG (60:9) tended to correlate negatively with body weight, body mass index, blood pressure, and HbA1c following fish oil intake.

conclusionCR and fish oil can ameliorate MetS features, including anthropometric parameters, blood pressure, and blood lipid concentrations. The levels of particular lipid species such as TG-containing docosapentaenoic acid were elevated post-intervention and negatively associated with MetS features. TG (60:9) may be proposed as a lipid metabolite to predict amelioration in MetS following the intake of CR and fish oil.

Indexed as

Caloric RestrictionDietFatty Acids, Omega-3LipidomicsAdultFish OilsHumansMaleMetabolic SyndromeMiddle AgedObesityFatty Acids, Omega-3Fish OilsCaloric restrictionClinical trialFish oilLipidomicsMetabolic syndromen-3 PUFA

Identifiers

PMID31865423
OpenAlexW2996147396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.