ArticleAnalytical and bioanalytical chemistry2020
Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor.
Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic and electrochemical viral detection for point-of-care use: A systematic review.PloS one · 2021Pooled it
- Sensitive detection of surface-mounted micrometer-thin cancer biomarkers and viruses using laser wave-mixing spectroscopy.Biomedical optics express · 2026Article
- Highly Sensitive Si-Based Electrolyte-Gated Transistor Array for Multiplexed Detection of Arboviruses.Micromachines · 2025Article
- Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit.Cell reports. Physical science · 2024Article
- Analysis of Clinical Samples of Pancreatic Cyst's Lesions with A Multi-Analyte Bioelectronic Simot Array Benchmarked Against Ultrasensitive Chemiluminescent Immunoassay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Study on the Flow Field Distribution in Microfluidic Cells for Surface Plasmon Resonance Array Detection.Materials (Basel, Switzerland) · 2024Article
- Influence of Surface Treatments on Urea Detection Using Si Electrolyte-Gated Transistors with Different Gate Electrodes.Micromachines · 2024Article
- Combining Bioorthogonal Chemistry with Fluorescent Silica Nanoparticles for the Ultrasensitive Detection of the HIV-1 p24 Antigen.ACS omega · 2024Article
- Advances in field-effect biosensors towards point-of-use.Nanotechnology · 2023Review
- Highly Sensitive Detection of Urea Using Si Electrolyte-Gated Transistor with Low Power Consumption.Biosensors · 2023Article
- A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing.Science advances · 2022Article
- Why a Diffusing Single-Molecule can be Detected in Few Minutes by a Large Capturing Bioelectronic Interface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- An Ultrasensitive Silicon-Based Electrolyte-Gated Transistor for the Detection of Peanut Allergens.Biosensors · 2022Article
- Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein.Biosensors · 2021Article
- Electrochemical diagnostics of infectious viral diseases: Trends and challenges.Biosensors & bioelectronics · 2021Review
- Review
- Synthesis, characterisation and cytotoxicity of gold microwires for ultra-sensitive biosensor development.Microbial cell factories · 2021Article
- Electrolyte-gated transistors for enhanced performance bioelectronics.Nature reviews. Methods primers · 2021Article
- ABC Spotlight on single-molecule detection.Analytical and bioanalytical chemistry · 2020Article
- Recent Advances in Biomolecule-Nanomaterial Heterolayer-Based Charge Storage Devices for Bioelectronic Applications.Materials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of the infection caused by human immunodeficiency virus type-1 (HIV-1) is vital to achieve efficient therapeutic treatment and limit the disease spreading when the viremia is at its highest level. To this end, a point-of-care HIV-1 detection carried out with label-free, low-cost, and ultra-sensitive screening technologies would be of great relevance. Herein, a label-free single molecule detection of HIV-1 p24 capsid protein with a large (wide-field) single-molecule transistor (SiMoT) sensor is proposed. The system is based on an electrolyte-gated field-effect transistor whose gate is bio-functionalized with the antibody against the HIV-1 p24 capsid protein. The device exhibits a limit of detection of a single protein and a limit of quantification in the 10 molecule range. This study paves the way for a low-cost technology that can quantify, with single-molecule precision, the transition of a biological organism from being "healthy" to being "diseased" by tracking a target biomarker. This can open to the possibility of performing the earliest possible diagnosis.
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