Evidence map›Paper›PMID 31865389›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2020

Left ventricular wall thickness assessed by cardiac computed tomography and cardiac resynchronization therapy outcomes.

Vincent Galand, Brian Ghoshhajra, Jackie Szymonifka, Saumya Das, Mary Orencole, Valentin Barré, Raphaël P Martins, Christophe Leclercq, Judy Hung, Quynh A Truong and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01097733 (Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01097733 completednot on this map

Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy

TypeobservationalSponsorMassachusetts General HospitalRan2009 to 2012Enrolled38ConditionsHeart Failure - NYHA II - IV, Wide QRS ComplexArmsRandomization of Pre-knowledge of CT coronary venography
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vincent GalandCardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, F-35000 Rennes, France.
Brian GhoshhajraCardiac MR PET CT Program, Division of Cardiology, Department of Radiology (Cardiovascular Imaging), Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jackie SzymonifkaDepartment of Public Health, Division of Biostatistics, New York University, New York, NY, USA.
Saumya DasCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Mary OrencoleCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Valentin BarréCardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, F-35000 Rennes, France.
Raphaël P MartinsCardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, F-35000 Rennes, France.
Christophe LeclercqCardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, F-35000 Rennes, France.
Judy HungCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Quynh A TruongDepartment of Radiology and Cardiology, Weill Cornell Medicine, New York, NY, USA.
Jagmeet P SinghCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

Funding

Computed Tomography to Predict Response to Cardiac Resynchronization TherapyK23HL098370 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI TRUONG, QUYNH A. · 2010 to 2014
$816k
NHLBI NIH HHS K23 HL098370NHLBI NIH HHS L30 HL093806
6 · The paper itself

Abstract

aimsUp to 30% of selected heart failure patients do not benefit clinically from cardiac resynchronization therapy (CRT). Left ventricular (LV) wall thickness (WT) analysed using computed tomography (CT) has rarely been evaluated in response to CRT and mitral regurgitation (MR) improvement. We examined the association of LVWT and the ability to reverse LV remodelling and MR improvement after CRT. METHODS AND

resultsFifty-four patients scheduled for CRT underwent pre-procedural CT. Reduced LVWT was defined as WT <6 mm and quantified as a percentage of total LV area. Endpoints were 6-month clinical and echocardiographic response to CRT [New York Heart Association (NYHA) class, LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic volume (LVESV)], MR improvement and 2-year major adverse cardiac events (MACE). Patients were divided into three groups according to the percentage of LVWT <6 mm area: ≤20%, 20-50%, and ≥50%. At 6 months, 75%, 71%, and 42% of the patients experienced NYHA improvement in the ≤20%, 20-50%, and ≥50% group, respectively. Additionally, ≤20% group presented higher LVEF, LVEDV, and LVESV positive response rate (86%, 59%, and 83%, respectively). Both 20-50% and ≥50% groups exhibited a lower LVEF, LVEDV, and LVESV positive response rate (52% and 42%; 47% and 45%; and 53% and 45%, respectively). Additionally, ≥25% of LVWT <6 mm inclusive of at least one papillary muscle insertion was the only predictor of lack of MR improvement. Lastly, ≥50% group experienced significantly lower 2-year MACE survival free probability.

conclusionWT evaluated using CT could help to stratify the response to CRT and predict MR improvement and outcomes. CLINICAL

trial registrationNCT01097733.

Indexed as

Cardiac Resynchronization TherapyHeart FailureHeart VentriclesHumansStroke VolumeTomographyTreatment OutcomeVentricular Function, LeftVentricular RemodelingCardiac resynchronization therapyComputed tomographyHeart failureLeft ventricular wall thicknessMitral regurgitationOutcomeResponse to cardiac resynchronization therapy

Identifiers

PMID31865389
PMCPMC7058969

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.