Evidence map›Paper›PMID 31865175›Full record

ArticleTranslational oncology2020

Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas.

Yiqiang Zhou, Yang Liu, Junwen Zhang, Di Yu, Aiguo Li, Hua Song, Wei Zhang, Dionne Davis, Mark R Gilbert, Fusheng Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Translational oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yiqiang ZhouNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yang LiuNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Junwen ZhangBrain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Laboratory of Biomedical Materials, Beijing 100050, China.
Di YuNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Aiguo LiNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hua SongNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Wei ZhangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Dionne DavisNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mark R GilbertNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Fusheng LiuBrain Tumor Research Center, Beijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Laboratory of Biomedical Materials, Beijing 100050, China. Electronic address: liufushengs@hotmail.com.
Chunzhang YangNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: yangc2@mail.nih.gov.
National Cancer Institute · USCenter for Cancer Research · USNational Institutes of Health · USBeijing Institute of Neurosurgery · CNCapital Medical University · CN

Funding

Brain Tumor Clinical and Clinical Research Program (Clinical Support Services)ZIDBC011642 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OZER, BYRAM · 2015 to 2025
$23.4M
Rare Central Nervous System Cancers InitiativeZIABC011643 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$4.2M
Identifying New Glioma-Associated Tumor Suppressors OncogenesZIABC011647 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$4.2M
Translational ImmunologyZIABC011714 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2016 to 2024
$4.0M
Investigation on the biology of IDH mutant gliomaZIABC011684 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YANG, CHUN ZHANG · 2016 to 2025
$3.6M
Exploring the Therapeutic Potential of Stem Cell Biology in GliomasZIABC011640 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$3.1M
6 · The paper itself

Abstract

The isocitrate dehydrogenase (IDH1/2) mutations are frequent genetic abnormalities in the majority of WHO grade II/III glioma and secondary GBM. IDH1-mutated (IDH1

Identifiers

PMID31865175
PMCPMC6926316
OpenAlexW2995292251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.