ArticleNeuroImage. Clinical2020
Functional brain connectome in posterior cortical atrophy.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Disrupted brain topological network and its association with clinical features in posterior cortical atrophy.Brain communications · 2026Article
- Functional network contributions to longitudinal tau spread in Posterior Cortical Atrophy.NPJ dementia · 2026Article
- Early classification of functional connectomes in Parkinson's disease: a comparison of machine learning classifiers using multi-scale topological features.BMC medical informatics and decision making · 2025Article
- Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants.Journal of Alzheimer's disease : JAD · 2025Article
- The alterations of repetitive transcranial magnetic stimulation on the energy landscape of resting-state networks differ across the human cortex.Human brain mapping · 2024Article
- Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease.Brain communications · 2024Article
- Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy.Brain : a journal of neurology · 2023Article
- EANM procedure guidelines for brain PET imaging using [European journal of nuclear medicine and molecular imaging · 2022Article
- Benson's Disease or Posterior Cortical Atrophy, Revisited.Journal of Alzheimer's disease : JAD · 2021Review
- Multi-class diagnosis of Alzheimer's disease using cascaded three dimensional-convolutional neural network.Physical and engineering sciences in medicine · 2020Article
- A future for PET imaging in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (CSF) examination for Alzheimer's disease (AD) biomarkers, cognitive assessment, and brain MRI. For a smaller subset of participants, FDG-PET examination was available. We assessed topological brain network properties and regional functional connectivity as well as intra- and inter-hemispheric connectivity, using graph analysis and connectomics. Supplementary analyses were performed to explore the association between the CSF AD profile and the connectome status, and taking into account hypometabolic, atrophic, and spared regions (nodes). PCA patients showed diffuse functional connectome alterations at both global and regional level, as well as a connectivity breakdown between the posterior brain nodes. They had a widespread loss of both intra- and inter-hemispheric connections, exceeding the structural damage, and including the frontal connections. In PCA, connectome alterations were identified in all the brain nodes irrespectively of their structural and metabolic classification and were associated with a connectivity breakdown between damaged and spared areas. Taken together, these findings suggest the potentially high sensitivity of graph-analysis and connectomic in capturing the progression and maybe early signs of neurodegeneration in PCA patients.
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