Evidence map›Paper›PMID 31864864›Full record

SynthesisThe American journal of emergency medicine2020

Diagnostic value of CT contrast extravasation for major arterial injury after pelvic fracture: A meta-analysis.

David Dreizin, Yuanyuan Liang, James Dent, Nabeel Akhter, Daniel Mascarenhas, Thomas M Scalea

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The American journal of emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Explainable Knowledge-Guided Algorithm for Contrast Extravasation Detection on Computed Tomography.IEEE journal of translational engineering in health and medicine · 2026
    Article
  3. Article
  4. Pelvic Trauma: Anatomy and Interventions.Seminars in interventional radiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David DreizinDepartment of Diagnostic Radiology and Nuclear Medicine, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, United States. Electronic address: daviddreizin@gmail.com.
Yuanyuan LiangDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address: yliang@som.umaryland.edu.
James DentDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Nabeel AkhterDepartment of Diagnostic Radiology and Nuclear Medicine, Vascular and Interventional Radiology, University of Maryland School of Medicine, United States. Electronic address: nakhter@umm.edu.
Daniel MascarenhasOrthopedic Surgery, Rutgers Robert Wood Johnson Medical School, United States.
Thomas M ScaleaFrancis X Kelly Distinguished Professor in Trauma Surgery, Physician in Chief, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, United States. Electronic address: tscalea@umm.edu.
University of Maryland, Baltimore · USRutgers, The State University of New Jersey · US

Funding

Machine learning-based segmentation and risk modeling for real-time prediction of major arterial bleeding after pelvic fracturesK08EB027141 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI DREIZIN, DAVID · 2019 to 2022
$745k
NIBIB NIH HHS K08 EB027141
6 · The paper itself

Abstract

purposeWe conducted a meta-analysis to determine diagnostic performance of CT intravenous contrast extravasation (CE) as a sign of angiographic bleeding and need for angioembolization after pelvic fractures. MATERIALS AND

methodsA systematic literature search combining the concepts of contrast extravasation, pelvic trauma, and CT yielded 206 potentially eligible studies. 23 studies provided accuracy data or sufficient descriptive data to allow 2x2 contingency table construction and provided 3855 patients for meta-analysis. Methodologic quality was assessed using the QUADAS-2 tool. Sensitivity and specificity were synthesized using bivariate mixed-effects logistic regression. Heterogeneity was assessed using the I2-statistic. Sources of heterogeneity explored included generation of scanner (64 row CT versus lower detector row) and use of multiphasic versus single phase scanning protocols.

resultsOverall sensitivity and specificity were 80% (95% CI: 66-90%, I2 = 92.65%) and 93% (CI: 90-96, I2 = 89.34%), respectively. Subgroup analysis showed pooled sensitivity and specificity of 94% and 89% for 64- row CT compared to 69% and 95% with older generation scanners. CE had pooled sensitivity and specificity of 95% and 92% with the use of multiphasic protocols, compared to 74% and 94% with single-phase protocols.

conclusionThe pooled sensitivity and specificity of 64-row CT was 94 and 89%. 64 row CT improves sensitivity of CE, which was 69% using lower detector row scanners. High specificity (92%) can be maintained by incorporating multiphasic scan protocols.

Indexed as

AdultArteriesComputed Tomography AngiographyExtravasation of Diagnostic and Therapeutic MaterialsFractures, BoneHemorrhageHumansMiddle AgedPelvic BonesPelvisSensitivity and Specificity

Identifiers

PMID31864864
PMCPMC7253336
OpenAlexW2991028661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.