ArticleAmerican journal of surgery2020
Synchronous metastatic colon cancer and the importance of primary tumor laterality - A National Cancer Database analysis of right- versus left-sided colon cancer.
Article in American journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis.Clinical and experimental medicine · 2023Pooled it
- A Methodological and Survival Comparison of NCDB and SEER Database for Colon Cancer Research.Journal of surgical oncology · 2025Article
- Primary tumor location impacts survival in colorectal cancer patients after primary resection: a population‑based propensity score matching cohort study.Journal of gastrointestinal oncology · 2023Article
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- Prognostic Factors in Stage IV Colorectal Cancer Patients With Resection of Liver and/or Pulmonary Metastases: A Population-Based Cohort Study.Frontiers in oncology · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe role of laterality for patients with synchronous metastatic colon cancer (SMCC) is not well-defined.
methodsUsing the National Cancer Database (2010-2015), we compared patients with metastatic right- (RCC) versus left-sided colon cancer (LCC). We performed Kaplan-Meier analysis to compare overall survival (OS) for each metastatic site and utilized adjusted Cox proportional hazard analysis to identify predictors of OS.
resultsPatients with RCCs were more likely to be older, female, and have more comorbidities. LCCs were more likely to metastasize to liver and lung, whereas RCCs were more likely to metastasize to peritoneum and brain. There was equal likelihood to metastasize to bone. OS was significantly longer for LCCs for all metastatic sites. After controlling for multiple variables, RCC (HR 1.426, p < 0.001) remained an independent predictor of worse OS compared to LCC.
conclusionsLaterality of the primary tumor plays an important role in outcomes for patients with SMCC.
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