Evidence map›Paper›PMID 31864415›Full record

ArticleActa neuropathologica communications2019

Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke.

Daniela Talhada, Joana Feiteiro, Ana Raquel Costa, Tiago Talhada, Elisa Cairrão, Tadeusz Wieloch, Elisabet Englund, Cecília Reis Santos, Isabel Gonçalves, Karsten Ruscher

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Local Thyroid Hormone Action in Brain Development.International journal of molecular sciences · 2023
    Review
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  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Plasticity-Enhancing Effects of Levodopa Treatment after Stroke.International journal of molecular sciences · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Daniela TalhadaLaboratory for Experimental Brain Research, Division of Neurosurgery, Department of Clinical Sciences, Lund University, BMC A13, S-22184, Lund, Sweden.
Joana FeiteiroCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Ana Raquel CostaCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Tiago TalhadaLaboratory for Experimental Brain Research, Division of Neurosurgery, Department of Clinical Sciences, Lund University, BMC A13, S-22184, Lund, Sweden.
Elisa CairrãoCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Tadeusz WielochLaboratory for Experimental Brain Research, Division of Neurosurgery, Department of Clinical Sciences, Lund University, BMC A13, S-22184, Lund, Sweden.
Elisabet EnglundDivision of Oncology and Pathology, Lund University Hospital, Lund, Sweden.
Cecília Reis SantosCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Isabel GonçalvesCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Karsten RuscherLaboratory for Experimental Brain Research, Division of Neurosurgery, Department of Clinical Sciences, Lund University, BMC A13, S-22184, Lund, Sweden. karsten.ruscher@med.lu.se.ORCID http://orcid.org/0000-0001-7211-2499
University of Beira Interior · PTLund University · SE

Funding

Fundação para a Ciência e a Tecnologia SFRH/BD/104679/2014Fundação para a Ciência e a Tecnologia Technology UID / Multi / 00709/2019Hjärnfonden FO2019-0254; FO2018-0316ICON 2020 CENTRO-01-0145-FEDER-000013
6 · The paper itself

Abstract

The development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic mechanisms during the first weeks after stroke will influence functional outcome. Thyroid hormones (TH) are essential regulators of neuronal plasticity, however, their role in recovery related mechanisms of neuronal plasticity after stroke remains unknown. This study addresses important findings of 3,5,3'-triiodo-L-thyronine (T

Indexed as

AnimalsBrainBrain IschemiaCells, CulturedDendritic SpinesHomeostasisHumansMaleMice, Inbred C57BLNeuronal PlasticityNeuronsNeuroprotective AgentsReceptors, Thyroid HormoneRecovery of FunctionStrokeSynaptotagminsNeuroprotective AgentsReceptors, Thyroid HormoneSynaptotagminsTriiodothyronine3,5,3′,5′-tetraiodo-L-thyronine (T4)3,5,3′-triiodo-L-thyronine (T3)IschemiaPhotothrombosisRecoveryStrokeThyroid hormone receptorsThyroid hormones

Identifiers

PMID31864415
PMCPMC6925884
OpenAlexW2996471614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.