ReviewParasites & vectors2019
A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.
Review in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Helminth Prevalence in European Deer with a Focus on Abomasal Nematodes and the Influence of Livestock Pasture Contact: A Meta-Analysis.Pathogens (Basel, Switzerland) · 2024Pooled it
- Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.Frontiers in public health · 2021Pooled it
- Tick-Borne Pathogens in Wild Cervids from Poland: A Molecular Survey onAnimals : an open access journal from MDPI · 2026Article
- Molecular Detection of Anaplasma spp. in Horses From Golestan Province, Northern Iran.Veterinary medicine and science · 2026Article
- Immuno-Informatics Design of Multi-Epitope Vaccine Candidate AgainstHealth science reports · 2026Article
- Early-life exposure to vector-borne pathogens in moose calves from Finland: molecular and phylogenetic evidence.BMC veterinary research · 2026Article
- Cerebrospinal Fluid Findings among Patients with Anaplasmosis and Central Nervous Involvement, Minnesota and Wisconsin, USA.Emerging infectious diseases · 2026Article
- Comparative Clinical Characteristics of ICU and Non-ICU Hospitalized Patients With Human Anaplasmosis.Open forum infectious diseases · 2026Article
- A novel ecotype of Anaplasma phagocytophilum complex in questing Ixodes fuscipes ticks.Parasites & vectors · 2026Article
- High diversity and distribution of ticks and tick-borne diseases in Sudan emphasizes the need for implementing cost-effective community One Health strategy.Frontiers in microbiology · 2026Review
- Exploration of geographical population structure ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Severe Thrombocytopenia and New Right Bundle Branch Block in Human Granulocytic Anaplasmosis: A Case Report.Journal of Brown hospital medicine · 2026Article
- Molecular detection and phylogenetic characterization ofFrontiers in cellular and infection microbiology · 2026Article
- A one-health approach to surveillance of tick-borne pathogens across different host groups.BMC veterinary research · 2025Article
- Epidemiological Significance of the Fox (Pathogens (Basel, Switzerland) · 2025Article
- Detection ofAnimals : an open access journal from MDPI · 2025Article
- Infections by Ehrlichia spp., Anaplasma spp. and Babesia spp. In Puerto Ordaz, Bolívar, VenezuelaBiomedica : revista del Instituto Nacional de Salud · 2025Article
- Seroprevalence ofMicroorganisms · 2025Article
- Impact of Human Granulocytic Anaplasmosis in Spain from 1997 to 2022.Tropical medicine and infectious disease · 2025Review
- Molecular Surveillance ofPathogens (Basel, Switzerland) · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 7 countries.
Funding
Abstract
Anaplasma phagocytophilum is the agent of tick-borne fever, equine, canine and human granulocytic anaplasmosis. The common route of A. phagocytophilum transmission is through a tick bite, the main vector in Europe being Ixodes ricinus. Despite the apparently ubiquitous presence of the pathogen A. phagocytophilum in ticks and various wild and domestic animals from Europe, up to date published clinical cases of human granulocytic anaplasmosis (HGA) remain rare compared to the worldwide status. It is unclear if this reflects the epidemiological dynamics of the human infection in Europe or if the disease is underdiagnosed or underreported. Epidemiologic studies in Europe have suggested an increased occupational risk of infection for forestry workers, hunters, veterinarians, and farmers with a tick-bite history and living in endemic areas. Although the overall genetic diversity of A. phagocytophilum in Europe is higher than in the USA, the strains responsible for the human infections are related on both continents. However, the study of the genetic variability and assessment of the difference of pathogenicity and infectivity between strains to various hosts has been insufficiently explored to date. Most of the European HGA cases presented as a mild infection, common clinical signs being pyrexia, headache, myalgia and arthralgia. The diagnosis of HGA in the USA was recommended to be based on clinical signs and the patient's history and later confirmed using specialized laboratory tests. However, in Europe since the majority of cases are presenting as mild infection, laboratory tests may be performed before the treatment in order to avoid antibiotic overuse. The drug of choice for HGA is doxycycline and because of potential for serious complication the treatment should be instituted on clinical suspicion alone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.