ArticleJournal of orthopaedic surgery and research2019
Associations between serum calcium, 25(OH)D level and bone mineral density in older adults.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
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- Article
- Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in theMedical sciences (Basel, Switzerland) · 2025Article
- Shared Genetic Architecture and Causal Relationship Between Serum 25-Hydroxyvitamin D and Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2025Article
- A novelHeliyon · 2024Article
- Combining OSTA and BMR to predict osteoporosis in Chinese population.Journal of orthopaedic surgery and research · 2024Article
- Serum 25-Hydroxyvitamin D Is Inversely Associated with Nasopharyngeal Carcinoma: A Hospital-Based Matched Case-Control Study in Malaysia.Nutrients · 2024Article
- Vertebral endplate defects are associated with bone mineral density in lumbar degenerative disc disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study.Scientific reports · 2022Article
- The correlation between serum total alkaline phosphatase and bone mineral density in young adults.BMC musculoskeletal disorders · 2022Article
- Associations between albumin, globulin, albumin to globulin ratio and muscle mass in adults: results from the national health and nutrition examination survey 2011-2014.BMC geriatrics · 2022Article
- Cosmetic use and serum level of lead (not cadmium) affect bone mineral density among young Iranian women.Environmental science and pollution research international · 2022Article
- Association between SEMA3A signaling pathway genes and BMD/OP risk: An epidemiological and experimental study.Frontiers in endocrinology · 2022Article
- Can waist circumference be a predictor of bone mineral density independent of BMI in middle-aged adults?Endocrine connections · 2021Article
- Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort.Journal of clinical medicine · 2021Article
- High-Intensity Physical Activity with High Serum Vitamin D Levels is Associated with a Low Prevalence of Osteopenia and Osteoporosis: A Population-Based Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Associations between Physical Activity, Sunshine Duration and Osteoporosis According to Obesity and Other Lifestyle Factors: A Nested Case-Control Study.International journal of environmental research and public health · 2021Article
- Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review.Journal of physiological anthropology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium and vitamin D play important roles in bone health as essential nutrients. We explored whether serum calcium, 25(OH)D were associated with bone mineral density (BMD) in older adults.
methodsThis cross-sectional study was conducted on a sample of 4595 participants (2281 men and 2314 women) aged ≥ 50 years (from 50 to 85 years, 60.1 ± 8.7 years for men and 62.0 ± 9.7 years for women) from the National Health and Nutrition Examination Survey (NHANES) 2001-2006. The independent variables were serum calcium and 25(OH)D. The dependent variable was lumbar BMD. The other variables were considered potential effect modifiers. We performed weighted multivariate linear regression models and smooth curve fittings to evaluate the associations between them. Subgroup analyses were also performed.
resultsWe observed a negative association between serum calcium and lumbar BMD in the fully adjusted model. In the subgroup analyses, this association was no longer significant among males and other race/ethnicity. On the other hand, there was a positive association between serum 25(OH)D and lumbar BMD in the fully adjusted model. In the subgroup analyses, this association did not differ in different age groups, between men and women. However, the association between serum 25(OH)D and lumbar BMD followed a U-shaped curve in Mexican Americans.
conclusionsThis cross-sectional study indicated that serum calcium negatively correlated with lumbar BMD, and serum 25(OH)D positively correlated with lumbar BMD in older adults. However, the association between serum calcium and lumbar BMD in males followed a U-shaped curve.
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