Evidence map›Paper›PMID 31864171›Full record

ArticleEpilepsy research2020

Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits.

S K Kang, S Ammanuel, D A Adler, S D Kadam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Discovery of Small Molecule KCC2 Potentiators Which AttenuateFrontiers in cell and developmental biology · 2022
    Article
  3. Article
  4. Novel Therapeutics for Neonatal Seizures.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

S K KangDepartment of Neuroscience, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA.
S AmmanuelDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
D A AdlerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
S D KadamDepartment of Neuroscience, Hugo Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA; Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: kadam@kennedykrieger.org.
Johns Hopkins University · USJohns Hopkins Medicine · USKennedy Krieger Institute · US

Funding

Mechanisms regulating KCC2 hypofunction during refractory seizures in a mouse model of ischemic neonatal seizuresR01HD090884 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCAFIDI, JOSEPH · 2017 to 2021
$1.9M
NICHD NIH HHS R01 HD090884
6 · The paper itself

Abstract

A recently characterized CD-1 mouse model of phenobarbital (PB)-resistant neonatal ischemic-seizures (i.e.; unilateral carotid ligation) was shown to be associated with age-dependent (P7 vs. P10) acute seizure severity and PB-efficacy (i.e.; PB-resistant vs. PB-responsive). ANA12, a novel small-molecule TrkB antagonist, rescued the PB-resistance at P7 in a dose-dependent manner and prevented the post-ischemic downregulation of KCC2, the chief Cl

Indexed as

AnimalsAnticonvulsantsAzepinesBenzamidesDisease Models, AnimalDose-Response Relationship, DrugElectroencephalographyElectromyographyMicePhenobarbitalReceptor, trkBSeizuresSpatial MemoryANA 12 compoundAnticonvulsantsAzepinesBenzamidesPhenobarbitalReceptor, trkBGamma oscillationsHyperactivityHypoxic-ischemic encephalopathyRefractory seizuresSleep dysfunction

Identifiers

PMID31864171
PMCPMC6953748
OpenAlexW2994054975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.