ReviewCurrent opinion in biotechnology2020
Tracing metabolic flux through time and space with isotope labeling experiments.
Review in Current opinion in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Sulfur Homeostasis in Rice as a Dynamic Regulatory Network: Functional Genomics, Metabolic Crosstalk, and miR395-Mediated Control.Molecular biotechnology · 2026Review
- Back to the roots: Cannabis sativa L. root metabolism, microbiomes, and biotechnological potential.Applied microbiology and biotechnology · 2026Review
- Metabolic rewiring and biomass redistribution enable optimized mixotrophic growth in Chlamydomonas.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Carbon Dioxide Release During Photosynthesis: Connecting Gas Exchange Behavior With Biochemistry.Plant, cell & environment · 2026Review
- Differential metabolic and regulatory responses to exogenous glucose uptake across plant species revealed by isotopic metabolomics.Frontiers in plant science · 2026Article
- Assessing and avoiding C isotopic contamination artefacts in mesocosm-scalePlant methods · 2025Article
- Non-canonical plant metabolism.Nature plants · 2025Review
- Metabolic flux analysis to increase oil in seeds.Plant physiology · 2025Review
- Stable Isotope Tracing Experiments Using LC-MS.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Deciphering sphingolipid biosynthesis dynamics iniScience · 2024Article
- Imaging plant metabolism in situ.Journal of experimental botany · 2024Review
- SIMPEL: using stable isotopes to elucidate dynamics of context specific metabolism.Communications biology · 2024Article
- Article
- Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives.Metabolomics : Official journal of the Metabolomic Society · 2023Review
- Article
- A simulation-free constrained regression approach for flux estimation in isotopically nonstationary metabolic flux analysis with applications in microalgae.Frontiers in plant science · 2023Article
- Recent metabolomic developments for antimalarial drug discovery.Parasitology research · 2022Review
- Metabolic synergy in Camelina reproductive tissues for seed development.Science advances · 2022Article
- 13CO2 labeling kinetics in maize reveal impaired efficiency of C4 photosynthesis under low irradiance.Plant physiology · 2022Article
- 13C-labeling reveals how membrane lipid components contribute to triacylglycerol accumulation in Chlamydomonas.Plant physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Metabolism is dynamic and must function in context-specific ways to adjust to changes in the surrounding cellular and ecological environment. When isotopic tracers are used, metabolite flow (i.e. metabolic flux) can be quantified through biochemical networks to assess metabolic pathway operation. The cellular activities considered across multiple tissues and organs result in the observed phenotype and can be analyzed to discover emergent, whole-system properties of biology and elucidate misconceptions about network operation. However, temporal and spatial challenges remain significant hurdles and require novel approaches and creative solutions. We survey current investigations in higher plant and animal systems focused on dynamic isotope labeling experiments, spatially resolved measurement strategies, and observations from re-analysis of our own studies that suggest prospects for future work. Related discoveries will be necessary to push the frontier of our understanding of metabolism to suggest novel solutions to cure disease and feed a growing future world population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.