Evidence map›Paper›PMID 31863793›Full record

ArticleAntiviral research2020

In silico and in vitro analysis of small molecules and natural compounds targeting the 3CL protease of feline infectious peritonitis virus.

Sirin Theerawatanasirikul, Chih Jung Kuo, Nanthawan Phetcharat, Porntippa Lekcharoensuk

Abstract read
In one paragraph

Article in Antiviral research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Veterinary sciences · 2024
    Article
  2. Article
  3. First study onVeterinary world · 2023
    Article
  4. Antiviral Properties ofPathogens (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Fighting coronaviruses with natural polyphenols.Biocatalysis and agricultural biotechnology · 2021
    Article
  11. Article
  12. Nanocarrier vaccines for SARS-CoV-2.Advanced drug delivery reviews · 2021
    Article
  13. Article
  14. Pharmacotherapeutics of SARS-CoV-2 Infections.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  15. Article
  16. A Multifunctional Peptide FromFrontiers in molecular biosciences · 2021
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sirin TheerawatanasirikulDepartment of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.
Chih Jung KuoDepartment of Veterinary Medicine, National Chung Hsing University, Taichung, 40227, Taiwan. Electronic address: ck476@nchu.edu.tw.
Nanthawan PhetcharatDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, 50th Ngamwongwan Rd., Ladyao, Chatuchak, Bangkok, 10900, Thailand.
Porntippa LekcharoensukDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, 50th Ngamwongwan Rd., Ladyao, Chatuchak, Bangkok, 10900, Thailand; Center of Advanced Studies in Agriculture and Food, KU Institute, Thailand. Electronic address: fvetptn@ku.ac.th.
Kasetsart University · THNational Chung Hsing University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The computational search of chemical libraries has been used as a powerful tool for the rapid discovery of candidate compounds. To find small molecules with anti-feline infectious peritonitis virus (FIPV) properties, we utilized a virtual screening technique to identify the active site on the viral protease for the binding of the available natural compounds. The protease 3CL (3CL

Indexed as

AnimalsAntiviral AgentsCatalytic DomainCatsComputer SimulationCoronavirus, FelineDrug Evaluation, PreclinicalFeline Infectious PeritonitisKineticsPeptide HydrolasesProtease InhibitorsRibavirinViral ProteinsAntiviral AgentsPeptide HydrolasesProtease InhibitorsRibavirinViral Proteins3CL proteaseAntiviral activityCoronavirusFeline infectious peritonitis virus (FIPV)Natural compoundsVirtual screening

Identifiers

PMID31863793
PMCPMC7114316
OpenAlexW2996685553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.