Evidence map›Paper›PMID 31863782›Full record

ArticleiScience2019

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function.

Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L Millhauser, Pietro Paolo Sanna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Syndecans modulate ghrelin receptor signaling.Journal of molecular endocrinology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jihuan ChenDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Valerie ChenDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Tomoya KawamuraDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ivy HoangDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yang YangDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ashley Tess WongDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
Ryan McBrideDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA; Genomics Core, The Scripps Research Institute, La Jolla, CA 92037, USA.
Vez Repunte-CanonigoDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Glenn L MillhauserDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Electronic address: glennm@ucsc.edu.
Pietro Paolo SannaDepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: psanna@scripps.edu.
Scripps Research Institute · USUniversity of California, Santa Cruz · US

Funding

Gene Network Perturbations in Alcohol Dependence - A Systems BiologyApproachR01AA021667 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2013 to 2026
$6.1M
Systems biology of HIV, methamphetamine and antiretrovirals interactionsR01DA041750 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KARAN, CHARLES, RISSMAN, ROBERT · 2016 to 2020
$4.4M
Identification of small molecules for neurological complications of HIV and substance abuse comorbidityR01DA046204 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI SANNA, PIETRO P, SPICER, TIMOTHY PATRICK · 2018 to 2022
$4.2M
Systems biology of RNA Modifications in HIV/AIDS and Substance Use DisordersR01DA046170 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI SANNA, PIETRO P · 2018 to 2022
$3.8M
Molecular Mechanisms of AgRP SignalingR01DK110403 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MILLHAUSER, GLENN L · 2017 to 2020
$1.7M
NIAAA NIH HHS R01 AA021667NIDA NIH HHS R01 DA041750NIDA NIH HHS R01 DA046170NIDA NIH HHS R01 DA046204NIDDK NIH HHS R01 DK110403
6 · The paper itself

Abstract

The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood. Mature AgRP

Indexed as

Obesity MedicinePhysiology

Identifiers

PMID31863782
PMCPMC6928319
OpenAlexW2988858531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.