Evidence map›Paper›PMID 31863658›Full record

ArticleCell journal2020

PolyI:C Upregulated CCR5 and Promoted THP-1-Derived Macrophage Chemotaxis via TLR3/JMJD1A Signalling.

Xiaoxiao Yu, Huayang Wang, Hongjia Shao, Cuijuan Zhang, Xiuli Ju, Jie Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaoxiao YuDepartment of Paediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Huayang WangDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hongjia ShaoDepartment of Paediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Cuijuan ZhangDepartment of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Xiuli JuDepartment of Paediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Jie YangDepartment of Paediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic Address yangj6466@163.com.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the specific roles of polyinosinic:polycytidylic acid (polyI:C) in macrophage chemotaxis and reveal the potential regulatory mechanisms related to chemokine receptor 5 ( MATERIALS AND

methodsIn this experimental study, THP-1-derived macrophages (THP1-Mφs) induced from THP- 1 monocytes were treated with 25 μg/mL polyI:C. Toll-like receptor 3 (

resultsPolyI:C significantly upregulated

conclusionPolyI:C can enhance THP1-Mφ chemotaxis toward CCL3 regulated by

Indexed as

Chemokine Receptor 5ChemotaxisMacrophagesPolyinosinic:polycytidylic Acid

Identifiers

PMID31863658
PMCPMC6947015
OpenAlexW2999861314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.