Evidence map›Paper›PMID 31863530›Full record

ArticleDrug and alcohol review2020

Contingency management treatment for methamphetamine use disorder in South Africa.

Chukwuemeka N Okafor, Dan J Stein, Lisa Dannatt, Jonathan Ipser, Lara J van Nunen, Marilyn T Lake, Tamar Krishnamurti, Edythe D London, Steve Shoptaw

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Chukwuemeka N OkaforDivision of Infectious Diseases, David Geffen School of Medicine at University of California, Los Angeles, USA.ORCID 0000-0002-6080-4866
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Lisa DannattDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Jonathan IpserDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Lara J van NunenDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Marilyn T LakeDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Tamar KrishnamurtiDivision of General Internal Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, USA.ORCID 0000-0002-3416-2230
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, USA.
Steve ShoptawDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAUniversity of California, Los Angeles · USSouth African Medical Research Council · ZAUniversity of Pittsburgh · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALDWIN, GAYLE COCITA · 1991 to 2018
$39.9M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
Combating craving with contingency management: neuroplasticity and methamphetamine abuse in South AfricaR21DA040492 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHOPTAW, STEVEN J · 2015 to 2017
$311k
NCATS NIH HHS KL2 TR001856NIAID NIH HHS P30 AI028697NIDA NIH HHS R21 DA040492NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

INTRODUCTION AND

aimsAs South Africa, especially the Western Cape Province, faces an epidemic of methamphetamine use disorder, therapeutic approaches suited to the South African context are needed. This secondary analysis assessed retention and methamphetamine abstinence outcomes in response to an 8-week pilot contingency management (CM) intervention trial of neural correlates of methamphetamine abstinence, exploring sociodemographic and clinical differences between responders and non-responders. DESIGN AND

methodsResearch participants provided thrice-weekly monitored urine samples, which were analysed by qualitative radioimmunoassay. The primary outcome for this analysis was therapeutic response, defined as abstinence from methamphetamine (≥23 of 24 possible methamphetamine-negative urine samples).

resultsData from 30 adults living in Cape Town, South Africa (34 ± 6.1 years of age, mean age ± SD, 21 men) were included. Sixty-three percent (12 men) were responders. In bivariate comparisons, baseline measurements showed fewer responders reported monthly household income ≥25 000+ South African Rand (ZAR; ~USD $1880; vs. ZAR < 25 000) than non-responders (15.8% vs. 63.6%; P = 0.007). Furthermore, responders had higher median years of education (12 vs. 10; Kruskal-Wallis χ DISCUSSION AND

conclusionsTherapeutic response in this study were comparable to those obtained with CM for methamphetamine use disorder in North America and Europe. Our findings suggest that CM may be a useful component of treatment strategies to boost retention and continuous abstinence from methamphetamine in Cape Town, South Africa. Larger efficacy studies are needed in this setting.

Indexed as

AdultAmphetamine-Related DisordersBehavior TherapyFemaleHumansMaleMethamphetamineMiddle AgedSouth AfricaMethamphetaminebehavioural treatmentcontingency managementmethamphetamine use disorderSouth Africastimulants

Identifiers

PMID31863530
PMCPMC7647047
OpenAlexW2995010865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.