Evidence map›Paper›PMID 31863510›Full record

ArticleThe European journal of neuroscience2020

Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.

Deirdre A Sackett, Travis M Moschak, Regina M Carelli

Open access · greenAbstract read
In one paragraph

Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Glucose Sensing in the Hepatic Portal Vein and Its Role in Food Intake and Reward.Cellular and molecular gastroenterology and hepatology · 2023
    Review
  5. A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Deirdre A SackettDepartment of Psychology and Neuroscience, The University of North Carolina, Chapel Hill, NC, USA.
Travis M MoschakDepartment of Psychology and Neuroscience, The University of North Carolina, Chapel Hill, NC, USA.
Regina M CarelliDepartment of Psychology and Neuroscience, The University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-5704-9812
University of North Carolina at Chapel Hill · US

Funding

Training on Research in Drug AbuseT32DA007244 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Regina M Carelli · 1990 to 2026
$7.6M
Neurobiological Investigation of Decision Making in RatsR01DA034021 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARELLI, REGINA M · 2013 to 2017
$1.7M
Neurobiological investigation of delay discounting: role of prelimbic cortex -> nucleus accumbens circuitF31DA042721 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SACKETT, DEIRDRE · 2016 to 2017
$65k
NIDA NIH HHS F31 DA042721NIDA NIH HHS R01 DA034021NIDA NIH HHS T32 DA007244NIH HHS DA034021
6 · The paper itself

Abstract

Effective decision-making depends on an animal's ability to predict and select the outcome of greatest value, and the nucleus accumbens (NAc) and its dopaminergic input play a key role in this process. We previously reported that rapid dopamine release in the NAc shell preferentially tracks the "preferred" (i.e., large reward) option during cues that predict the ability to respond for rewards of different sizes, as well as during reward delivery itself. The present study assessed whether shell dopamine release at these discrete times selectively mediated choice behavior for rewards of different magnitudes using optogenetics. Here, using Long Evans TH:Cre

Indexed as

DopamineNucleus AccumbensAnimalsDecision MakingRatsRats, Long-EvansRewardDopamineaccumbensdecision-makingdopamineoptogeneticsrat

Identifiers

PMID31863510
PMCPMC8234437
OpenAlexW2995248214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.