Evidence map›Paper›PMID 31863354›Full record

SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2020

Oncologic impact of micrometastases or isolated tumor cells in sentinel lymph nodes of patients with endometrial cancer: a meta-analysis.

N R Gómez-Hidalgo, P T Ramirez, B Ngo, S Pérez-Hoyos, N Coreas, J L Sanchez-Iglesias, S Cabrera, S Franco, A P Benavente, A Gil-Moreno

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04403867 (The Role of Micrometastasis and Isolated Tumor Cells), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04403867 recruitingnot on this map

The Role of Micrometastasis and Isolated Tumor Cells (ITCs) in Uterine Cancers (Endometrial/Cervical) Submitted to Sentinel Lymph Nodes (SLN) Procedure: an Observational Study

TypeobservationalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2020 to 2027Enrolled500ConditionsEndometrial Cancer, Cervical Cancer, Sentinel Lymph Node, MicrometastasisArmsSentinel lymph node (SLN) biosy +/- lymphadenectomy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

N R Gómez-HidalgoUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. nrodriguez.gh@gmail.com.ORCID http://orcid.org/0000-0002-5115-6668
P T RamirezDepartment of Gynecology Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
B NgoSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
S Pérez-HoyosStatistics and Bioinformatics Unit, Vall DHebron Research Institute (VHIR), Statistics Department, Faculty of Biology, University of Barcelona, Barcelona, Spain.
N CoreasInstituto Salvadoreño del Seguro Social (ISSS), El Salvador University, El Salvador, USA.
J L Sanchez-IglesiasUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
S CabreraUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
S FrancoUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
A P BenaventeUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
A Gil-MorenoUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vall d'Hebron Barcelona Hospital Campus, Autonoma University of Barcelona, UAB, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Hebron University · PSCornell University · USThe University of Texas MD Anderson Cancer Center · USUniversitat de Barcelona · ESUniversity of El Salvador · SV

Funding

Mechanisms and Models of Chromosomal Instability in CancerF99CA234950 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI NGO, BRYAN D · 2018 to 2019
$91k
NCI NIH HHS F99 CA234950
6 · The paper itself

Abstract

purposeThere is a gap in knowledge regarding the impact of micrometastases (MIC) and isolated tumor cells (ITCs) found in the sentinel lymph nodes of patients with endometrial cancer. Here, we present a meta-analysis of the published literature on the rate of MIC and ITCs after lymphatic mapping and determine trends in postoperative management.

methodsLiterature search of Medline and PubMed was done using the terms: micrometastases, isolated tumor cells, endometrial cancer, and sentinel lymph node. Inclusion criteria were: English-language manuscripts, retrospectives, or prospective studies published between January 1999 and June 2019. We removed manuscripts on sentinel node mapping that did not specify information on micrometastases or isolated tumor cells, non-English-language articles, no data about oncologic outcomes, and articles limited to ten cases or less.

resultsA total of 45 manuscripts were reviewed, and 8 studies met inclusion criteria. We found that the total number of patients with MIC/ITCs was 286 (187 and 99, respectively). The 72% of patients detected with MIC/ITCs in sentinel nodes received adjuvant therapies. The MIC/ITCs group has a higher relative risk of recurrence of 1.34 (1.07, 1.67) than the negative group, even if the adjuvant therapy was given.

conclusionWe noted that there is an increased relative risk of recurrence in patients with low-volume metastases, even after receiving adjuvant therapy. Whether adjuvant therapy is indicated remains a topic of debate because there are other uterine factors implicated in the prognosis. Multi-institutional tumor registries may help shed light on this important question.

Indexed as

Neoplasm Recurrence, LocalSentinel Lymph Node BiopsyEndometrial NeoplasmsFemaleHumansNeoplasm MicrometastasisProspective StudiesRetrospective StudiesSentinel Lymph NodeEndometrial cancerIsolated tumor cellsMicrometastasesSentinel lymph node

Identifiers

PMID31863354
PMCPMC7992114
OpenAlexW2995052632

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.