Evidence map›Paper›PMID 31863345›Full record

ArticleCEN case reports2020

A case of lupus vasculopathy presenting favorable renal outcome.

Yuri Ishizaki, Ayako Aizawa, Shoko Ochiai, Akihiro Minakawa, Shunichi Miyauchi, Kunihiko Umekita, Yuji Sato, Yayoi Ogawa, Yoshio Kushida, Akihiko Okayama and 2 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Yuri IshizakiDepartment of Nephrology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. yuri_ishizaki@med.miyazaki-u.ac.jp.
Ayako AizawaDepartment of Rheumatology and Infectious Diseases, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Shoko OchiaiDepartment of Nephrology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Akihiro MinakawaDepartment of Nephrology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Shunichi MiyauchiDepartment of Rheumatology and Infectious Diseases, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kunihiko UmekitaDepartment of Rheumatology and Infectious Diseases, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yuji SatoDepartment of Nephrology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Yayoi OgawaDepartment of Pathology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Yoshio KushidaDepartment of Diagnostic Pathology, Kagawa University Hospital, Kagawa, Japan.
Akihiko OkayamaDepartment of Rheumatology and Infectious Diseases, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Noriko UesugiDepartment of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan.
Shouichi FujimotoDepartment of Nephrology, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
University of Miyazaki Hospital · JPUniversity of Miyazaki · JPFukuoka University · JPHokkaido University · JPKagawa University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noninflammatory necrotizing vasculopathy, also referred to as lupus vasculopathy, is not infrequently observed in the pathology of lupus nephritis. It affects vessels causing them to become severely narrowed and occluded by a mechanism involving immune complexes. We experienced a 51-year-old woman with lupus nephritis class IV + V, which was accompanied by lupus vasculopathy. Renal biopsy and light microscopy showed eosinophilic hyaline-like material in the afferent and/or efferent arterioles, which narrowed the lumen, and which were positive for IgG by immunofluorescent analysis. Electron microscopy indicated that amorphous material and endothelial detachment occluded the arterioles. These findings were consistent with those of lupus vasculopathy. We treated the patient with steroids and cyclophosphamide. By the day of discharge, her levels of creatinine and proteinuria had undergone partial remission. Although lupus vasculopathy was implied as a lesion with unfavorable renal prognosis, some recent reports suggest its true renal prognosis is not unfavorable necessarily. Nevertheless, lupus vasculopathy is an important finding in diagnosis in contradiction to other vascular legions in systemic lupus erythematosus. In addition, a standard therapy has also not been established. Therefore, it is important to accumulate cases of lupus vasculopathy to determine its prognosis and develop standard treatments.

Indexed as

Adrenal Cortex HormonesArteriolesBiopsyCreatinineCyclophosphamideDrug Therapy, CombinationFluorescent Antibody TechniqueHumansImmunosuppressive AgentsKidneyLupus NephritisMicroscopy, ElectronMiddle AgedPrognosisProteinuriaVascular DiseasesAdrenal Cortex HormonesCreatinineCyclophosphamideImmunosuppressive AgentsLupus nephritisLupus vasculopathyNoninflammatory necrotizing vasculopathy

Identifiers

PMID31863345
PMCPMC6990287
OpenAlexW2995931803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.