Evidence map›Paper›PMID 31863341›Full record

ArticleInternational journal of hematology2020

Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation.

Shin-Ichi Tsujimoto, Ryota Shirai, Tomoyuki Utano, Tomoo Osumi, Kana Matsumoto, Yoko Shioda, Chikako Kiyotani, Toru Uchiyama, Takao Deguchi, Keita Terashima and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Shin-Ichi TsujimotoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Ryota ShiraiChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Tomoyuki UtanoDepartment of Pharmaceuticals, National Center for Child Health and Development, Tokyo, Japan.
Tomoo OsumiChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Kana MatsumotoDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan.
Yoko ShiodaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Chikako KiyotaniChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Toru UchiyamaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Takao DeguchiChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Keita TerashimaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Daisuke TomizawaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Kimikazu MatsumotoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Motohiro KatoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan. katom-tky@umin.ac.jp.ORCID http://orcid.org/0000-0001-5145-1774
National Center For Child Health and Development · JP

Funding

a grant from the National Center for Child Health and Development 28-5Research Foundation for Clinical Pharmacology Clinical Pharmacology
6 · The paper itself

Abstract

Antiseizure prophylaxis is required during busulfan administration for hematopoietic stem cell transplantation. However, antiseizure agents such as benzodiazepines and phenytoin may produce adverse effects through interaction with other drugs. We retrospectively assessed the prophylactic efficacy and safety of levetiracetam and clonazepam against busulfan-induced seizures between 2013 and 2018. Thirty patients (after 2015) received levetiracetam, and 13 patients (before 2015) received clonazepam in this study. Levetiracetam was well-tolerated and had a significantly lower frequency of adverse effects, such as somnolence, compared with clonazepam, although two patients in the levetiracetam group experienced seizures. Levetiracetam is a feasible option for preventing busulfan-induced seizures.

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentBusulfanChildChild, PreschoolClonazepamFemaleHumansLevetiracetamMaleRetrospective StudiesSeizuresTreatment OutcomeBusulfanClonazepamLevetiracetamBusulfan-induced seizureClonazepamLevetiracetam

Identifiers

PMID31863341
OpenAlexW2996211827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.