Evidence map›Paper›PMID 31863324›Full record

ReviewJournal of muscle research and cell motility2020

Cardiac tissue engineering therapeutic products to enhance myocardial contractility.

Kathleen M Broughton, Mark A Sussman

Abstract readReview
In one paragraph

Review in Journal of muscle research and cell motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kathleen M BroughtonDepartment of Biology and Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA.
Mark A SussmanDepartment of Biology and Heart Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA. heartman4ever@icloud.com.

Funding

Regulation of Signal Transduction to Treat Heart FailureR01HL067245 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2001 to 2021
$6.0M
Resolving myocardial regeneration by tracking commitment of c-Kit+ cellsR01HL135661 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GUDE, NATALIE ALLEN, SUSSMAN, MARK ALAN · 2017 to 2020
$1.7M
Enhanced Myocardial Repair with CardioClusters and CardioChimerasR01HL122525 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2014 to 2017
$1.5M
Chromatin Content and Regenerative Potential of Cardiac Progenitor CellsF32HL136196 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI BROUGHTON, KATHLEEN · 2017 to 2018
$118k
Fondation Leducq 13CVD01NHLBI NIH HHS F32HL136196NHLBI NIH HHS R01 HL067245NHLBI NIH HHS R01HL067245NHLBI NIH HHS R01 HL122525NHLBI NIH HHS R01HL122525NHLBI NIH HHS R01 HL135661
6 · The paper itself

Abstract

Researchers continue to develop therapeutic products for the repair and replacement of myocardial tissue that demonstrates contractility equivalent to normal physiologic states. As clinical trials focused on pure adult stem cell populations undergo meta-analysis for preclinical through clinical design, the field of tissue engineering is emerging as a new clinical frontier to repair the myocardium and improve cardiac output. This review will first discuss the three primary tissue engineering product themes that are advancing in preclinical to clinical models: (1) cell-free scaffolds, (2) scaffold-free cellular, and (3) hybrid cell and scaffold products. The review will then focus on the products that have advanced from preclinical models to clinical trials. In advancing the cardiac regenerative medicine field, long-term gains towards discovering an optimal product to generate functional myocardial tissue and eliminate heart failure may be achieved.

Indexed as

AnimalsContractureHumansMyocardiumRatsRats, Sprague-DawleyTissue EngineeringClinical trialsHeart failureTherapiesTissue engineering

Identifiers

PMID31863324
PMCPMC7305042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.