SynthesisBrain structure & function2020
Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation.
Synthesis in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Do You Match What I Match? A Systematic Review of Over 20 Years of the Emotional Face Matching Task Reveals Vast Inconsistencies in Design and Implementation.Human brain mapping · 2026Pooled it
- Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review.Translational psychiatry · 2024Pooled it
- Convergent functional changes of the episodic memory impairment in mild cognitive impairment: An ALE meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
- Stereo-Electroencephalography Reveals Dynamic Spatio-Spectral Signatures of Negative Emotions: A Distributed Circuit Mechanism Involving Amygdala-Cingulate-Hippocampus-Orbitofrontal Networks.Brain and behavior · 2025Article
- Mobile application leads to psychological improvement and correlated neuroimmune function change in subjective cognitive decline.NPJ digital medicine · 2025Article
- Differences in Emotional Awareness Moderate Cytokine-Symptom Associations Among Breast Cancer Survivors.Brain, behavior, and immunity · 2025Article
- Investigating the effect of mindfulness training for stress management in military training: the relationship between the autonomic nervous system and emotional regulation.BMC psychology · 2025Article
- Imaging joy with generalized slice dithered enhanced resolution and SWAT reconstruction: 3T high spatial-temporal resolution fMRI.Frontiers in neuroimaging · 2025Article
- Article
- Imaging of the brain-heart axis: prognostic value in a European setting.European heart journal · 2024Article
- Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes.Biology of sex differences · 2024Article
- Relationships between serotonin availability and frontolimbic response to fearful and threatening faces.Scientific reports · 2023Article
- Functional differentiation of the dorsal striatum: a coordinate-based neuroimaging meta-analysis.Quantitative imaging in medicine and surgery · 2023Article
- Different topological patterns in structural covariance networks between high and low delay discounters.Frontiers in psychology · 2023Article
- GABAFrontiers in neuroscience · 2023Article
- Continuity versus change in latent profiles of emotion regulation and working memory during adolescence.Developmental cognitive neuroscience · 2022Article
- Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect.European child & adolescent psychiatry · 2022Article
- Remembering past challenges to feel better today: Role of neural dedifferentiation and autobiographical integration in late-life reappraisal.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Anatomically interconnected, the ventromedial prefrontal cortex (vmPFC) and amygdala interact in emotion processing. However, no meta-analyses have focused on studies that reported concurrent vmPFC and amygdala activities. With activation likelihood estimation (ALE) we examined 100 experiments that reported concurrent vmPFC and amygdala activities, and distinguished responses to positive vs. negative emotions and to passive exposure to vs. active regulation of emotions. We also investigated whole-brain experiments for other regional activities. ALE and contrast analyses identified convergent anterior and posterior vmPFC response to passive positive and negative emotions, respectively, and a subregion in between to mixed emotions. A smaller area in the posterior ventral vmPFC is specifically involved in regulation of negative emotion. Whereas bilateral amygdala was involved during emotional exposure, only the left amygdala showed convergent activities during active regulation of negative emotions. Whole-brain analysis showed convergent activity in left ventral striatum for passive exposure to positive emotions and downregulation of negative emotions, and in the posterior cingulate cortex and ventral precuneus for passive exposure to negative emotions. These findings highlight contrasting, valence-specific subregional vmPFC as well as other regional responses during passive exposure to emotions. The findings also suggest that hyperactivation of the vmPFC is associated with diminished right amygdala activities during regulation of negative emotions. Together, the findings extend the literature by specifying the roles of subregional vmPFC and amygdala activities in emotion processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.