Evidence map›Paper›PMID 31863144›Full record

ReviewApplied microbiology and biotechnology2020

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives.

R U Haque, F Paradisi, T Allers

Abstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Isolation of a lipase-producing strain from yuncheng salt lake and enhancement of lipase activity via UV mutagenesis.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Article
  3. Review
  4. Recent Advances in Understanding Bio-Compounds from Haloarchaea.Journal of microbiology and biotechnology · 2026
    Review
  5. Article
  6. Microbial conversion of biodiesel waste for carotenoid production.Frontiers in bioengineering and biotechnology · 2026
    Article
  7. Hydrostatic pressure-enabled transformation inFrontiers in microbiology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Journal of bacteriology · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Microbial Bacterioruberin: A Comprehensive Review.Indian journal of microbiology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

R U HaqueSchool of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.ORCID https://orcid.org/0000-0003-1513-459X
F ParadisiSchool of Chemistry, University Park, University of Nottingham, Nottingham, NG7 2RD, UK.ORCID https://orcid.org/0000-0003-1704-0642
T AllersSchool of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK. thorsten.allers@nottingham.ac.uk.ORCID https://orcid.org/0000-0002-7308-3332

Funding

Biotechnology and Biological Sciences Research Council BB/P002536/1
6 · The paper itself

Abstract

Haloferax volcanii is an obligate halophilic archaeon with its origin in the Dead Sea. Simple laboratory culture conditions and a wide range of genetic tools have made it a model organism for studying haloarchaeal cell biology. Halophilic enzymes of potential interest to biotechnology have opened up the application of this organism in biocatalysis, bioremediation, nanobiotechnology, bioplastics and the biofuel industry. Functionally active halophilic proteins can be easily expressed in a halophilic environment, and an extensive genetic toolkit with options for regulated protein overexpression has allowed the purification of biotechnologically important enzymes from different halophiles in H. volcanii. However, corrosion mediated damage caused to stainless-steel bioreactors by high salt concentrations and a tendency to form biofilms when cultured in high volume are some of the challenges of applying H. volcanii in biotechnology. The ability to employ expressed active proteins in immobilized cells within a porous biocompatible matrix offers new avenues for exploiting H. volcanii in biotechnology. This review critically evaluates the various application potentials, challenges and toolkits available for using this extreme halophilic organism in biotechnology.

Indexed as

BiocatalysisBiofilmsBioreactorsCells, ImmobilizedHaloferax volcaniiIndustrial MicrobiologyProteomicsBiotechnologyHaloferax volcaniiImmobilizationModel organismProtein expression

Identifiers

PMID31863144
PMCPMC6985049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.