Evidence map›Paper›PMID 31863073›Full record

ArticleScientific reports2019

Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion.

Anna Keppner, Darko Maric, Chloé Sergi, Camille Ansermet, Damien De Bellis, Denise V Kratschmar, Jérémie Canonica, Petra Klusonova, Robert A Fenton, Alex Odermatt and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Renal KFrontiers in physiology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. ENaC activation by proteases.Acta physiologica (Oxford, England) · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Anna KeppnerDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-7880-3810
Darko MaricDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Chloé SergiDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Camille AnsermetDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Damien De BellisDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Denise V KratschmarDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Jérémie CanonicaDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Petra KlusonovaDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Alex OdermattDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-6820-2712
Gilles CrambertINSERM, Paris, France.
David HoogewijsDepartment of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.
Edith HummlerDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland. Edith.Hummler@unil.ch.ORCID https://orcid.org/0000-0002-3887-2715
University of Lausanne · CHUniversity of Basel · CHUniversity of Fribourg · CHAarhus University · DKHôpital Ophtalmique Jules-Gonin · CHInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kidney needs to adapt daily to variable dietary K

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 2Adaptor Proteins, Signal TransducingAnimalsAquaporin 2Blotting, WesternElectrophoresis, Polyacrylamide GelEnzyme-Linked Immunosorbent AssayKidneyMaleMembrane ProteinsMicePotassium, DietaryReceptors, GlucocorticoidReverse Transcriptase Polymerase Chain ReactionSerine EndopeptidasesSolute Carrier Family 12, Member 111-beta-Hydroxysteroid Dehydrogenase Type 2Adaptor Proteins, Signal TransducingAqp2 protein, mouseAquaporin 2Membrane ProteinsPotassium, DietaryReceptors, GlucocorticoidSerine EndopeptidasesSlc12a1 protein, mouseSolute Carrier Family 12, Member 1Tmprss4 protein, mouse

Identifiers

PMID31863073
PMCPMC6925205
OpenAlexW2996015696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.