Evidence map›Paper›PMID 31863037›Full record

ArticleScientific reports2019

Cleaved CD31 as a target for in vivo molecular imaging of inflammation.

Jonathan Vigne, Sylvie Bay, Rachida Aid-Launais, Guillaume Pariscoat, Guillaume Rucher, Jean Sénémaud, Ariane Truffier, Nadège Anizan, Guillaume Even, Christelle Ganneau and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Jonathan VigneNuclear Medicine Department, X. Bichat Hospital, APHP and DHU FIRE, F-75018, Paris, France. jonathan.vigne.fr@gmail.com.ORCID http://orcid.org/0000-0002-6575-9224
Sylvie BayUnité Chimie des Biomolécules, Département Biologie Structurale et Chimie, Institut Pasteur, Paris, France.
Rachida Aid-LaunaisUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Guillaume PariscoatNuclear Medicine Department, X. Bichat Hospital, APHP and DHU FIRE, F-75018, Paris, France.
Guillaume RucherUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Jean SénémaudUniversité de Paris, UMS34 FRIM, F-75018, Paris, France.
Ariane TruffierUnité Chimie des Biomolécules, Département Biologie Structurale et Chimie, Institut Pasteur, Paris, France.
Nadège AnizanUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Guillaume EvenUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Christelle GanneauUnité Chimie des Biomolécules, Département Biologie Structurale et Chimie, Institut Pasteur, Paris, France.
Francesco AndreataUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Marie Le BorgneUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.ORCID http://orcid.org/0000-0002-3439-4867
Antonino NicolettiUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Dominique Le GuludecNuclear Medicine Department, X. Bichat Hospital, APHP and DHU FIRE, F-75018, Paris, France.
Giuseppina CaligiuriUniversité de Paris, LVTS, INSERM U1148, F-75018, Paris, France.
Francois RouzetNuclear Medicine Department, X. Bichat Hospital, APHP and DHU FIRE, F-75018, Paris, France.ORCID http://orcid.org/0000-0001-6109-0087
Inserm · FRCentre National de la Recherche Scientifique · FRInstitut Pasteur · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a need for new targets to specifically localize inflammatory foci, usable in a wide range of organs. Here, we hypothesized that the cleaved molecular form of CD31 is a suitable target for molecular imaging of inflammation. We evaluated a bioconjugate of D-P8RI, a synthetic peptide that binds all cells with cleaved CD31, in an experimental rat model of sterile acute inflammation. Male Wistar rats were injected with turpentine oil into the gastrocnemius muscle two days before

Indexed as

AnimalsAutoradiographyChromatography, GelChromatography, High Pressure LiquidInflammationMagnetic Resonance ImagingMaleMicroscopy, FluorescencePlatelet Endothelial Cell Adhesion Molecule-1Positron-Emission TomographyProtein BindingRatsRats, WistarSingle Photon Emission Computed Tomography Computed TomographyPlatelet Endothelial Cell Adhesion Molecule-1

Identifiers

PMID31863037
PMCPMC6925130
OpenAlexW2995460670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.