Evidence map›Paper›PMID 31863033›Full record

ArticleScientific reports2019

Corticostriatal functional connectivity of bothersome tinnitus in single-sided deafness.

Jennifer Henderson-Sabes, Yingying Shang, Philip L Perez, Jolie L Chang, Seth E Pross, Anne M Findlay, Danielle Mizuiri, Leighton B Hinkley, Srikantan S Nagarajan, Steven W Cheung

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Jennifer Henderson-SabesDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
Yingying ShangDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
Philip L PerezDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
Jolie L ChangDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
Seth E ProssDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0003-4044-6296
Anne M FindlayDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Danielle MizuiriDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Leighton B HinkleyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
Srikantan S NagarajanDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.
Steven W CheungDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA. Steven.Cheung@ucsf.edu.ORCID http://orcid.org/0000-0003-1724-4944
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subjective tinnitus is an auditory phantom perceptual disorder without an objective biomarker. Bothersome tinnitus in single-sided deafness (SSD) is particularly challenging to treat because the deaf ear can no longer be stimulated by acoustic means. We contrasted an SSD cohort with bothersome tinnitus (TIN; N = 15) against an SSD cohort with no or non-bothersome tinnitus (NO TIN; N = 15) using resting-state functional magnetic resonance imaging (fMRI). All study participants had normal hearing in one ear and severe or profound hearing loss in the other. We evaluated corticostriatal functional connectivity differences by placing seeds in the caudate nucleus and Heschl's Gyrus (HG) of both hemispheres. The TIN cohort showed increased functional connectivity between the left caudate and left HG, and left and right HG and the left caudate. Within the TIN cohort, functional connectivity between the right caudate and cuneus was correlated with the Tinnitus Functional Index (TFI) relaxation subscale. And, functional connectivity between the right caudate and superior lateral occipital cortex, and the right caudate and anterior supramarginal gyrus were correlated with the TFI control subscale. These findings support a striatal gating model of tinnitus and suggest tinnitus biomarkers to monitor treatment response and to target specific brain areas for innovative neuromodulation therapies.

Indexed as

AdultAuditory CortexBrain MappingDeafnessFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTinnitus

Identifiers

PMID31863033
PMCPMC6925178
OpenAlexW2996563517

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.