Evidence map›Paper›PMID 31862952›Full record

ArticleScientific reports2019

Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak.

Pallab Ghosh, Yan Zhou, Quentin Richardson, Darren E Higgins

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Neuroimmune Consequences of L. monocytogenes Infection.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Review
  4. Article
  5. Analysis of Clinical and Microbiological Features ofInfection and drug resistance · 2023
    Article
  6. Article
  7. Article
  8. Rhombencephalitis due toThe Journal of international medical research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pallab GhoshDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Yan ZhouDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Quentin RichardsonDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Darren E HigginsDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. darren_higgins@hms.harvard.edu.
Boston VA Research Institute · USHarvard University · US

Funding

Diversity in Biomedical Sciences Via Personalized Research and Education Programs for Post-BaccalaureatesR25GM109436 · NIGMS · HARVARD UNIVERSITY · PI D'SOUZA, VICTORIA MANUEL, VELEZ-RUIZ, GISSELLE A · 2016 to 2024
$2.5M
Mechanisms regulating vimentin-dependent invasion of the brain by Listeria monocytogenesR01AI146102 · NIAID · HARVARD MEDICAL SCHOOL · PI BRUMELL, JOHN HUNTER, HIGGINS, DARREN E · 2019 to 2022
$1.6M
Listeria Monocytogenes Infection of the BrainR21AI103806 · NIAID · HARVARD MEDICAL SCHOOL · PI HIGGINS, DARREN E · 2014 to 2015
$466k
NIAID NIH HHS R01 AI146102NIAID NIH HHS R21 AI103806NIGMS NIH HHS R25 GM109436
6 · The paper itself

Abstract

Listeria monocytogenes is an intracellular pathogen responsible for listeriosis, a foodborne disease that can lead to life-threatening meningitis. The 2011 L. monocytogenes cantaloupe outbreak was among the deadliest foodborne outbreaks in the United States. We conducted in vitro and in vivo infection analyses to determine whether strains LS741 and LS743, two clinical isolates from the cantaloupe outbreak, differ significantly from the common laboratory strain 10403S. We showed that LS741 and LS743 exhibited increased virulence, characterized by higher colonization of the brain and other organs in mice. Assessment of cellular immune responses to known CD8

Indexed as

Disease OutbreaksAnimalsBacterial ToxinsCD8-Positive T-LymphocytesCucumis meloFemaleFoodborne DiseasesFood MicrobiologyHeat-Shock ProteinsHeLa CellsHemolysin ProteinsHumansListeria monocytogenesListeriosisMiceMice, Inbred BALB CBacterial ToxinsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenes

Identifiers

PMID31862952
PMCPMC6925182
OpenAlexW2995528840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.