ArticleScientific reports2019
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Born to resist: Understanding natural resistance to Haemonchus contortus in sheep.PLoS pathogens · 2026Article
- Comparison of Th-2 Cytokines and Associated Gene Expression in Peripheral Blood of Resistant and Susceptible Garole Sheep Infected WithJournal of parasitology research · 2026Article
- Timing ofFrontiers in immunology · 2026Article
- The adaptability of Garut sheep grazing on oil palm and rubber plantations in tropical conditions of Indonesia.Veterinary world · 2024Article
- Secretory IgA as Biomarker for Gastrointestinal Nematodes Natural Infection in Different Breed Sheep.Animals : an open access journal from MDPI · 2023Article
- Helminth-associated changes in host immune phenotype connect top-down and bottom-up interactions during co-infection.Functional ecology · 2023Article
- Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium.Veterinary and animal science · 2023Article
- Haemonchosis in Sheep and Goats, Control Strategies and Development of Vaccines againstAnimals : an open access journal from MDPI · 2022Review
- Response of Rambouillet Lambs to an Artificial Gastrointestinal Nematode Infection.Animals : an open access journal from MDPI · 2022Article
- Early Transcriptome Differences Between Pre-Infected and Naïve Kid Goats Infected WithFrontiers in veterinary science · 2022Article
- Variants Within GenesFrontiers in genetics · 2022Article
- Ovine haemonchosis: a review.Tropical animal health and production · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
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Registered trials
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